N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethylpiperidin-4-yl)picolinamide

Base Information

Chemical Name:N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethylpiperidin-4-yl)picolinamide
CAS No.:1351521-42-0
Molecular Formula:C₂₇H₃₄N₆O₃
Molecular Weight:490.605
Hs Code.:

Synonyms:N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethylpiperidin-4-yl)picolinamide

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Chemical Property of N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethylpiperidin-4-yl)picolinamide

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Technology Process of N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethylpiperidin-4-yl)picolinamide

There total 7 articles about N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethylpiperidin-4-yl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1351521-42-0
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethylpiperidin-4-yl)picolinamide

Guidance literature:

Reference yield:

: 29682-15-3
methyl 5-bromopicolinate

: 1351521-42-0
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethylpiperidin-4-yl)picolinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 0.17 h / 140 °C / Inert atmosphere; Microwave irradiation

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 20 - 55 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.17 h

4.2: 3 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6.1: sodium cyanoborohydride / methanol / 3 h / 0 - 20 °C / pH Ca_. 4

With hydrogenchloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium 10% on activated carbon; water; hydrogen; sodium cyanoborohydride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/ml300214g