Technology Process of 2-ethynyl-1H-indole-1-carboxamide
There total 5 articles about 2-ethynyl-1H-indole-1-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Echavarren's catalyst;
In
dichloromethane;
at 18 ℃;
for 24h;
Inert atmosphere;
DOI:10.1021/ol4007986
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methyllithium lithium bromide / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 18 °C / Inert atmosphere
1.2: 24 h / 60 °C / Inert atmosphere
2.1: dichloromethane / 2 h / 0 - 18 °C / Inert atmosphere
3.1: sodium hydrogencarbonate / methanol; water / 24 h / 18 °C
4.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 20 h / 18 - 80 °C / Inert atmosphere
5.1: Echavarren's catalyst / dichloromethane / 24 h / 18 °C / Inert atmosphere
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); methyllithium lithium bromide; Echavarren's catalyst; sodium hydrogencarbonate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
1.2: |Sonogashira Cross-Coupling / 4.1: |Sonogashira Cross-Coupling;
DOI:10.1021/ol4007986
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / methanol; water / 24 h / 18 °C
2: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 20 h / 18 - 80 °C / Inert atmosphere
3: Echavarren's catalyst / dichloromethane / 24 h / 18 °C / Inert atmosphere
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); Echavarren's catalyst; sodium hydrogencarbonate; triethylamine;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
2: |Sonogashira Cross-Coupling;
DOI:10.1021/ol4007986