2-(CHLOROMETHYL)-7-METHYL-5H-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE

Base Information

• Chemical Name: 2-(CHLOROMETHYL)-7-METHYL-5H-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE
• CAS No.: 81516-46-3
• Molecular Formula: C₇H₆ClN₃OS
• Molecular Weight: 215.663
• Mol file: 81516-46-3.mol

Synonyms:2-chloromethyl-7-methyl-5-oxo-5H-1,3,4-thiadiazolo<3,2-a>pyrimidine

Chemical Property of 2-(CHLOROMETHYL)-7-METHYL-5H-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(chloromethyl)-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one ^*data from reagent suppliers

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Technology Process of 2-(CHLOROMETHYL)-7-METHYL-5H-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE

There total 3 articles about 2-(CHLOROMETHYL)-7-METHYL-5H-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

ethyl acetoacetate (141-97-9) + thiosemicarbazide (79-19-6) + chloroacetic acid (79-11-8) → 2-chloromethyl-7-methyl-5-oxo-5H-1,3,4-thiadiazolo<3,2-a>pyrimidine (81516-46-3)

Guidance literature:

DOI:10.1007/BF00717354

Reference yield: 37.8%

chloroacetic acid (79-11-8) + 1-amino-4-methyl-6-oxo-2(3H)-pyrimidinethione (35523-72-9) → 2-chloromethyl-7-methyl-5-oxo-5H-1,3,4-thiadiazolo<3,2-a>pyrimidine (81516-46-3)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; at 70 ℃; for 10h;

DOI:10.1246/bcsj.55.637

Reference yield:

ethyl acetoacetate (141-97-9) + 5-(chloromethyl)-1,3,4-thiadiazol-2-amine (62774-00-9) → 2-chloromethyl-7-methyl-5-oxo-5H-1,3,4-thiadiazolo<3,2-a>pyrimidine (81516-46-3)

Guidance literature:

With PPA; at 95 - 100 ℃; for 3h; Yield given;

upstream raw materials:

ethyl acetoacetate

5-(chloromethyl)-1,3,4-thiadiazol-2-amine

chloroacetic acid

1-amino-4-methyl-6-oxo-2(3H)-pyrimidinethione

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