4-bromo-1-chloro-2-((4-(ethoxy-d5)phenyl)methyl-d2)benzene

Base Information

• Chemical Name: 4-bromo-1-chloro-2-((4-(ethoxy-d5)phenyl)methyl-d2)benzene
• CAS No.: 1204219-42-0
• Molecular Formula: C₁₅H₁₄BrClO
• Molecular Weight: 332.577
• Mol file: 1204219-42-0.mol

Synonyms:4-bromo-1-chloro-2-((4-(ethoxy-d5)phenyl)methyl-d2)benzene

Chemical Property of 4-bromo-1-chloro-2-((4-(ethoxy-d5)phenyl)methyl-d2)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-1-chloro-2-((4-(ethoxy-d5)phenyl)methyl-d2)benzene

There total 8 articles about 4-bromo-1-chloro-2-((4-(ethoxy-d5)phenyl)methyl-d2)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.8%

4-((5-bromo-2-chlorophenyl)methyl-d2)phenol (1204219-40-8) + 4-methylbenzenesulfonic acid [D5]ethyl ester (59034-23-0) → 4-bromo-1-chloro-2-((4-(ethoxy-d5)phenyl)methyl-d2)benzene (1204219-42-0)

Guidance literature:

With potassium carbonate; In acetone; at 25 ℃; Reflux;

Reference yield: 83.0%

→ 4-bromo-1-chloro-2-((4-(ethoxy-d5)phenyl)methyl-d2)benzene (1204219-42-0)

Guidance literature:

Reference yield:

(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone (461432-22-4) → 4-bromo-1-chloro-2-((4-(ethoxy-d5)phenyl)methyl-d2)benzene (1204219-42-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aluminum (III) chloride; sodium borodeuteride / tetrahydrofuran / 5 - 70 °C

2.1: boron tribromide / dichloromethane / -60 - 25 °C

2.2: Cooling with ice

3.1: potassium carbonate / acetone / 25 °C / Reflux

With aluminum (III) chloride; sodium borodeuteride; boron tribromide; potassium carbonate; In tetrahydrofuran; dichloromethane; acetone;

upstream raw materials:

ethanol-d6

4-((5-bromo-2-chlorophenyl)methyl-d2)phenol

4-methylbenzenesulfonic acid [D₅]ethyl ester

(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone

Downstream raw materials:

(3R,4S,5S,6R)-2-(4-chloro-3-((4-(ethoxy-d5)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(ethoxy-d5)phenyl)-methyl-d2)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(ethoxy-d5)phenyl)-methyl-d2)phenyl)-2-d-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol