[1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

Base Information

Chemical Name:[1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester
CAS No.:207235-12-9
Molecular Formula:C₃₇H₃₀FN₅O₇
Molecular Weight:675.673
Hs Code.:

[1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

Synonyms:[1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

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Chemical Property of [1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

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Technology Process of [1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

There total 7 articles about [1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 207235-88-9
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-methoxybenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

: 207235-12-9
[1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

Guidance literature:: With dichloro-acetic acid; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In toluene; at 20 ℃; for 3.5h;
DOI:10.1021/jm000496v

Reference yield:

: 59830-60-3,63219-70-5,68474-26-0
N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

: 207235-12-9
[1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

2: HCl / CHCl₃ / 3 h / 0 °C

3: ethanol / 6 h / Heating

4: H₂ / 10percent Pd/C / methanol / 18 h / 20 °C

5: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C

6: 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; dichloroacetic acid; DMSO / toluene / 3.5 h / 20 °C

With hydrogenchloride; dichloro-acetic acid; hydrogen; dimethyl sulfoxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 10percent Pd/C; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 6: modified Pfitzner-Moffatt oxidation;
DOI:10.1021/jm000496v

Reference yield:

: 20734-76-3
2-amino-4-methoxyphenol

: 207235-12-9
[1-{[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 6 h / Heating

2: H₂ / 10percent Pd/C / methanol / 18 h / 20 °C

3: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C

4: 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; dichloroacetic acid; DMSO / toluene / 3.5 h / 20 °C

With dichloro-acetic acid; hydrogen; dimethyl sulfoxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In methanol; ethanol; N,N-dimethyl-formamide; toluene; 4: modified Pfitzner-Moffatt oxidation;
DOI:10.1021/jm000496v