S-{2-[6-(benzyloxy)-5-cyano-4-methoxypyridin-3-yl]ethyl} ethanethioate

Base Information

Chemical Name:S-{2-[6-(benzyloxy)-5-cyano-4-methoxypyridin-3-yl]ethyl} ethanethioate
CAS No.:1257073-02-1
Molecular Formula:C₁₈H₁₈N₂O₃S
Molecular Weight:342.419
Hs Code.:

Synonyms:S-{2-[6-(benzyloxy)-5-cyano-4-methoxypyridin-3-yl]ethyl} ethanethioate

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Chemical Property of S-{2-[6-(benzyloxy)-5-cyano-4-methoxypyridin-3-yl]ethyl} ethanethioate

Chemical Property:

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Technology Process of S-{2-[6-(benzyloxy)-5-cyano-4-methoxypyridin-3-yl]ethyl} ethanethioate

There total 5 articles about S-{2-[6-(benzyloxy)-5-cyano-4-methoxypyridin-3-yl]ethyl} ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1257073-01-0
2-[6-(benzyloxy)-5-cyano-4-methoxypyridin-3-yl]ethyl 4-methylbenzenesulfonate

: 10387-40-3
potassium thioacetate

: 1257073-02-1
S-{2-[6-(benzyloxy)-5-cyano-4-methoxypyridin-3-yl]ethyl} ethanethioate

Guidance literature:: In N,N-dimethyl-formamide; acetonitrile; for 16h;

Reference yield:

: 21642-98-8
4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1257073-02-1
S-{2-[6-(benzyloxy)-5-cyano-4-methoxypyridin-3-yl]ethyl} ethanethioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide / 1,2-dichloro-ethane / Reflux

2.1: silver(l) oxide / toluene / 20.5 h / 107 - 120 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C

3.2: 16 h / -78 - 20 °C

4.1: dmap; triethylamine / dichloromethane / 24 h

5.1: N,N-dimethyl-formamide; acetonitrile / 16 h

With dmap; N-iodo-succinimide; n-butyllithium; triethylamine; silver(l) oxide; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1257072-93-7
5-iodo-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1257073-02-1
S-{2-[6-(benzyloxy)-5-cyano-4-methoxypyridin-3-yl]ethyl} ethanethioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver(l) oxide / toluene / 20.5 h / 107 - 120 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C

2.2: 16 h / -78 - 20 °C

3.1: dmap; triethylamine / dichloromethane / 24 h

4.1: N,N-dimethyl-formamide; acetonitrile / 16 h

With dmap; n-butyllithium; triethylamine; silver(l) oxide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;