2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole
• CAS No.: 1005203-14-4
• Molecular Formula: C₁₈H₁₄N₂O₃S
• Molecular Weight: 338.387
• Mol file: 1005203-14-4.mol

Synonyms:2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole

Chemical Property of 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole

There total 3 articles about 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.7%

2-methyl-5-{3-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole (1005201-23-9) → 2-methyl-5-{3-[4-(methylsulfonyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole (1005201-25-1) + 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole (1005203-15-5) + 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole (1005203-14-4)

Guidance literature:

With bis(acetylacetonate)oxovanadium; (S)‐N‐(1‐hydroxymethylisobutyl)(3,5‐di‐tert‐butylsalicylidene); dihydrogen peroxide; In dichloromethane; at 0 ℃; for 28h; optical yield given as %ee; enantioselective reaction;

DOI:10.1248/cpb.58.1252

Reference yield: 49.0%

2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole (1005201-24-0) → 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole (1005203-15-5) + 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole (1005203-14-4)

Guidance literature:

With CHIRALPAK AS; In ethanol; optical yield given as %ee; Resolution of racemate;

DOI:10.1021/jm900647e

Reference yield:

2-methyl-5-{3-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole (1005201-23-9) → 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole (1005203-15-5) + 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole (1005203-14-4)

Guidance literature:

With titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; Cumene hydroperoxide; water; In dichloromethane; at 0 ℃; for 24h; optical yield given as %ee; enantioselective reaction;

DOI:10.1248/cpb.58.1252

upstream raw materials:

2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole

2-methyl-5-{3-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole