(S)-2-Benzyloxycarbonylamino-6-(2-tert-butoxycarbonylamino-benzoylamino)-hexanoic acid 4-nitro-benzyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-6-(2-tert-butoxycarbonylamino-benzoylamino)-hexanoic acid 4-nitro-benzyl ester
CAS No.:174658-18-5
Molecular Formula:C₃₃H₃₈N₄O₉
Molecular Weight:634.686
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-6-(2-tert-butoxycarbonylamino-benzoylamino)-hexanoic acid 4-nitro-benzyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-6-(2-tert-butoxycarbonylamino-benzoylamino)-hexanoic acid 4-nitro-benzyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-6-(2-tert-butoxycarbonylamino-benzoylamino)-hexanoic acid 4-nitro-benzyl ester

There total 5 articles about (S)-2-Benzyloxycarbonylamino-6-(2-tert-butoxycarbonylamino-benzoylamino)-hexanoic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 174658-18-5
(S)-2-Benzyloxycarbonylamino-6-(2-tert-butoxycarbonylamino-benzoylamino)-hexanoic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / aq. 0.5 N NaOH / dioxane; acetonitrile / 8 h / Ambient temperature

2: 30 percent / WSC, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

3: 122.2 mg / diisopropylethylamine / dimethylformamide; methanol; ethyl acetate / 16 h / Ambient temperature

4: WSC, DMAP / CH₂Cl₂; acetonitrile / 4 h / Ambient temperature

With dmap; sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja952220w

Reference yield:

: 68790-38-5
2-(tert-butyloxycarbonylamino)benzoic acid

: 174658-18-5
(S)-2-Benzyloxycarbonylamino-6-(2-tert-butoxycarbonylamino-benzoylamino)-hexanoic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 30 percent / WSC, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

2: 122.2 mg / diisopropylethylamine / dimethylformamide; methanol; ethyl acetate / 16 h / Ambient temperature

3: WSC, DMAP / CH₂Cl₂; acetonitrile / 4 h / Ambient temperature

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja952220w

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 174658-18-5
(S)-2-Benzyloxycarbonylamino-6-(2-tert-butoxycarbonylamino-benzoylamino)-hexanoic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / aq. 0.5 N NaOH / dioxane; acetonitrile / 8 h / Ambient temperature

2: 30 percent / WSC, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

3: 122.2 mg / diisopropylethylamine / dimethylformamide; methanol; ethyl acetate / 16 h / Ambient temperature

4: WSC, DMAP / CH₂Cl₂; acetonitrile / 4 h / Ambient temperature

With dmap; sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja952220w