1-((1,2,3,4)-2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-5-methyl-2,4-(1H,3H)-pyrimidinedione

Base Information

Chemical Name:1-((1,2,3,4)-2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-5-methyl-2,4-(1H,3H)-pyrimidinedione
CAS No.:110864-91-0
Molecular Formula:C₁₁H₁₅FN₂O₄
Molecular Weight:258.25
Hs Code.:

Synonyms:2,4(1H,3H)-Pyrimidinedione,1-[2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-5-methyl-, (1a,2a,3b,4a)- (9CI);2,4(1H,3H)-Pyrimidinedione,1-[2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-5-methyl-, (1a,2a,3b,4a)-(?à)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((1,2,3,4)-2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-5-methyl-2,4-(1H,3H)-pyrimidinedione

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：95.58000
Density:1.45g/cm³
LogP:-0.49040

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-((1,2,3,4)-2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-5-methyl-2,4-(1H,3H)-pyrimidinedione

There total 3 articles about 1-((1,2,3,4)-2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-5-methyl-2,4-(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110864-90-9
(+/-)-(6aα,8β,9β,9aβ)-8-<(2,4-dinitrophenyl)amino>-9-fluorohexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin

: 110864-91-0
(+/-)-1-<(1α,2α,3β,4α)-2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-methyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

2: 1.) Dowex 2(OH^-) resin, 2.) 1N HCl / 1.) acetone, water, RT, 24 h

3: 1.) DBU, 2.) 2N HCl / 1.) DMF, a.) RT, 30 min, b.) -20 deg C, 30 min, c.) RT, 1.5 h, 2.) reflux, 3 h

With hydrogenchloride; Dowex 2(OH^-) resin; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;
DOI:10.1021/jm00163a030

Reference yield:

: 123169-13-1
(+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

: 110864-91-0
(+/-)-1-<(1α,2α,3β,4α)-2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-methyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Dowex 2(OH^-) resin, 2.) 1N HCl / 1.) acetone, water, RT, 24 h

2: 1.) DBU, 2.) 2N HCl / 1.) DMF, a.) RT, 30 min, b.) -20 deg C, 30 min, c.) RT, 1.5 h, 2.) reflux, 3 h

With hydrogenchloride; Dowex 2(OH^-) resin; 1,8-diazabicyclo[5.4.0]undec-7-ene;
DOI:10.1021/jm00163a030

Reference yield:

: 110864-92-1
3-ethoxy-2-methyl-2-propenoyl isocyanate

: 110312-76-0
(+/-)-(1α,2β,3α,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt

: 110864-91-0
(+/-)-1-<(1α,2α,3β,4α)-2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-methyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; Yield given. Multistep reaction; 1.) DMF, a.) RT, 30 min, b.) -20 deg C, 30 min, c.) RT, 1.5 h, 2.) reflux, 3 h;
DOI:10.1021/jm00163a030