6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester
CAS No.:1154527-30-6
Molecular Formula:C₃₆H₄₄ClN₃O₆
Molecular Weight:650.215
Hs Code.:

6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester

Synonyms:6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester

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Chemical Property of 6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester

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Technology Process of 6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester

There total 2 articles about 6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1154527-29-3
6-benzyloxy-3-[8aR-(4-hydroxy-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester

: 1154527-30-6
6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: 6-benzyloxy-3-[8aR-(4-hydroxy-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester; With 2,4,6-trimethyl-pyridine; methanesulfonyl chloride; lithium chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 120h;

With sodium hydrogencarbonate; In water; Saturated solution;
DOI:10.1016/j.tet.2008.08.102

Reference yield:

: 1154527-50-0
6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3R-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester

: 1154527-30-6
6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium hydride; In benzene; Reflux;
DOI:10.1016/j.tet.2008.08.102

Reference yield:

: 1154527-30-6
6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester

: C₃₁H₃₅N₃O₄

: 1154527-31-7
C₃₆H₄₃N₃O₆

Guidance literature:: 6-benzyloxy-3-[8aR-(4-chloro-3-methyl-but-2E-enyl)-1-methoxy-8S-methyl-4-oxo-3,4,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-3S-ylmethyl]-7-methoxy-indole-1-carboxylic acid tert-butyl ester; With sodium hydride; In 5,5-dimethyl-1,3-cyclohexadiene; at 135 ℃; for 1h;

With water; sodium hydrogencarbonate; In 5,5-dimethyl-1,3-cyclohexadiene; for 0.166667h; diastereoselective reaction; Cooling with ice;
DOI:10.1016/j.tet.2008.08.102