(S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-7-methanesulfonylamino-7-oxo-heptanoic acid

Base Information

Chemical Name:(S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-7-methanesulfonylamino-7-oxo-heptanoic acid
CAS No.:1026030-72-7
Molecular Formula:C₃₅H₄₂FN₅O₉S
Molecular Weight:727.811
Hs Code.:

(S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-7-methanesulfonylamino-7-oxo-heptanoic acid

Synonyms:(S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-7-methanesulfonylamino-7-oxo-heptanoic acid

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Chemical Property of (S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-7-methanesulfonylamino-7-oxo-heptanoic acid

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Technology Process of (S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-7-methanesulfonylamino-7-oxo-heptanoic acid

There total 3 articles about (S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-7-methanesulfonylamino-7-oxo-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026618-89-2
(S)-2-Benzyloxycarbonylamino-7-methanesulfonylamino-7-oxo-heptanoic acid benzyl ester

: 1026030-72-7
(S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-7-methanesulfonylamino-7-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / acetic acid / 2 h / 20 °C

2: HOBT; Et₃N / dimethylformamide; dimethylsulfoxide / 0.75 h / 20 °C

With hydrogen; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Hydrogenation / 2: Condensation;
DOI:10.1021/jm9803727

Reference yield:

: (S)-2-Benzyloxycarbonylamino-heptanedioic acid 1-benzyl ester

: 1026030-72-7
(S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-7-methanesulfonylamino-7-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 24 h / 20 °C

2: H₂ / 10 percent Pd/C / acetic acid / 2 h / 20 °C

3: HOBT; Et₃N / dimethylformamide; dimethylsulfoxide / 0.75 h / 20 °C

With dmap; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrogenation / 3: Condensation;
DOI:10.1021/jm9803727

Reference yield:

: 153538-13-7
pentafluorophenyl 4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>-2-fluorobenzoate

: 1027322-92-4
(S)-2-Amino-7-methanesulfonylamino-7-oxo-heptanoic acid

: 1026030-72-7
(S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-7-methanesulfonylamino-7-oxo-heptanoic acid

Guidance literature:: With benzotriazol-1-ol; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 20 ℃; for 0.75h;
DOI:10.1021/jm9803727