(S)-benzyl 2-((S)-1-((S)-1-tert-butoxy-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 2-((S)-1-((S)-1-tert-butoxy-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)pyrrolidine-1-carboxylate
CAS No.:1432576-77-6
Molecular Formula:C₂₇H₄₁N₃O₆
Molecular Weight:503.639
Hs Code.:

Synonyms:(S)-benzyl 2-((S)-1-((S)-1-tert-butoxy-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-benzyl 2-((S)-1-((S)-1-tert-butoxy-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-benzyl 2-((S)-1-((S)-1-tert-butoxy-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

There total 5 articles about (S)-benzyl 2-((S)-1-((S)-1-tert-butoxy-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13211-31-9
tert-butyl L-valinate

: C₂₃H₃₂N₂O₆S

: 1432576-77-6
(S)-benzyl 2-((S)-1-((S)-1-tert-butoxy-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: C₂₃H₃₂N₂O₆S; With silver tetrafluoroborate; In acetonitrile; at 20 ℃; for 0.0833333h; Inert atmosphere;

tert-butyl L-valinate; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol401053y

Reference yield:

: 13211-31-9
tert-butyl L-valinate

: 1432576-77-6
(S)-benzyl 2-((S)-1-((S)-1-tert-butoxy-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver tetrafluoroborate / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: trimethylsulphonium iodide / acetonitrile / 2 h / 20 °C / Inert atmosphere

4.1: silver tetrafluoroborate / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With silver tetrafluoroborate; trimethylsilyl trifluoromethanesulfonate; trimethylsulphonium iodide; In acetonitrile;
DOI:10.1021/ol401053y

Reference yield:

: C₁₈H₂₃NO₅S

: 1432576-77-6
(S)-benzyl 2-((S)-1-((S)-1-tert-butoxy-3-methyl-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver tetrafluoroborate / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: trimethylsulphonium iodide / acetonitrile / 2 h / 20 °C / Inert atmosphere

4.1: silver tetrafluoroborate / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With silver tetrafluoroborate; trimethylsilyl trifluoromethanesulfonate; trimethylsulphonium iodide; In acetonitrile;
DOI:10.1021/ol401053y