1-(bromoethynyl)-3-methoxylbenzene

Base Information

• Chemical Name: 1-(bromoethynyl)-3-methoxylbenzene
• CAS No.: 33675-45-5
• Molecular Formula: C₉H₇BrO
• Molecular Weight: 211.058
• Mol file: 33675-45-5.mol

Synonyms:1-(bromoethynyl)-3-methoxylbenzene

Chemical Property of 1-(bromoethynyl)-3-methoxylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(bromoethynyl)-3-methoxylbenzene

There total 4 articles about 1-(bromoethynyl)-3-methoxylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-ethynyl-3-methoxybenzene (768-70-7) → 1-(bromoethynyl)-3-methoxylbenzene (33675-45-5)

Guidance literature:

With N-Bromosuccinimide; silver nitrate; In acetone; at 20 ℃; Inert atmosphere; Darkness;

DOI:10.1021/acs.orglett.8b03987

Reference yield: 94.0%

1,1-dibromo-2-(3-methoxyphenyl)ethene (253684-23-0) → 1-(bromoethynyl)-3-methoxylbenzene (33675-45-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl acetamide; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201700217

Reference yield:

3-methoxy-benzaldehyde (591-31-1) → 1-(bromoethynyl)-3-methoxylbenzene (33675-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine / dichloromethane / 5.25 h / 0 °C / Inert atmosphere

2: N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide / dichloromethane; water / 5 h / 0 °C

With N-benzyl-N,N,N-triethylammonium chloride; triphenylphosphine; potassium hydroxide; In dichloromethane; water;

DOI:10.1021/ol5016898

upstream raw materials:

1-ethynyl-3-methoxybenzene

3-methoxy-1-iodobenzene

1,1-dibromo-2-(3-methoxyphenyl)ethene

3-methoxy-benzaldehyde

Downstream raw materials:

5-(3-methoxyphenyl)-2-phenyl-1H-imidazole