(+/-)-(Z)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate

Base Information

Chemical Name:(+/-)-(Z)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate
CAS No.:1364268-07-4
Molecular Formula:C₂₅H₂₆F₃N₃O₃S
Molecular Weight:505.561
Hs Code.:

Synonyms:(+/-)-(Z)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate

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Chemical Property of (+/-)-(Z)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate

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Technology Process of (+/-)-(Z)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate

There total 8 articles about (+/-)-(Z)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364268-04-1
C₂₅H₂₄F₃N₃O₃S

: 1364268-07-4
(+/-)-(Z)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate

Guidance literature:: With Lindlar's catalyst; hydrogen; In methanol; at 20 ℃;
DOI:10.1021/jm201683b

Reference yield:

: 1364267-98-0
methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((4-methoxybenzyl)oxy)benzoate

: 1364268-07-4
(+/-)-(Z)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 1.5 h / 0 - 20 °C

3: Lindlar's catalyst; hydrogen / methanol / 20 °C

With di-tert-butyl-diazodicarboxylate; Lindlar's catalyst; hydrogen; triphenylphosphine; trifluoroacetic acid; In methanol; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1021/jm201683b

Reference yield:

: 1364268-01-8
methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-hydroxybenzoate

: 1364268-07-4
(+/-)-(Z)-methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 1.5 h / 0 - 20 °C

2: Lindlar's catalyst; hydrogen / methanol / 20 °C

With di-tert-butyl-diazodicarboxylate; Lindlar's catalyst; hydrogen; triphenylphosphine; In methanol; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jm201683b