trans-4-(3-fluoro-pyridine-4-carbonyl)-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:trans-4-(3-fluoro-pyridine-4-carbonyl)-cyclohexanecarboxylic acid methyl ester
CAS No.:1345045-52-4
Molecular Formula:C₁₄H₁₆FNO₃
Molecular Weight:265.284
Hs Code.:

Synonyms:trans-4-(3-fluoro-pyridine-4-carbonyl)-cyclohexanecarboxylic acid methyl ester

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Chemical Property of trans-4-(3-fluoro-pyridine-4-carbonyl)-cyclohexanecarboxylic acid methyl ester

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Technology Process of trans-4-(3-fluoro-pyridine-4-carbonyl)-cyclohexanecarboxylic acid methyl ester

There total 2 articles about trans-4-(3-fluoro-pyridine-4-carbonyl)-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.9%

: 372-47-4
3-Fluoropyridine

: 32529-80-9,36218-60-7
trans-1-chlorocarbonyl-4-(methoxycarbonyl)-cyclohexane

: 1345045-52-4
trans-4-(3-fluoro-pyridine-4-carbonyl)-cyclohexanecarboxylic acid methyl ester

: 1345045-51-3
trans-4-(3-fluoro-pyridine-2-carbonyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: 3-Fluoropyridine; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; at -78 - -60 ℃; for 3h;

With zinc(II) chloride; In diethyl ether; hexane; at -60 - 20 ℃; for 0.75h;

trans-1-chlorocarbonyl-4-(methoxycarbonyl)-cyclohexane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; hexane; for 16h;

Reference yield:

: 15177-67-0
trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid

: 1345045-52-4
trans-4-(3-fluoro-pyridine-4-carbonyl)-cyclohexanecarboxylic acid methyl ester

: 1345045-51-3
trans-4-(3-fluoro-pyridine-2-carbonyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 24 h / 0 - 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane; diethyl ether / 3 h / -78 - -60 °C

2.2: 0.75 h / -60 - 20 °C

2.3: 16 h

With n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; N,N-dimethyl-formamide; In diethyl ether; hexane; dichloromethane; 2.3: Negishi Coupling Reaction;