(3R,5S,5aR,8aS)-5-[2-(4-methoxyphenylmethyloxy)ethyl]-3-phenylhexahydro-1,4-dioxa-3a-azacyclopenta[c]pentalene

Base Information

Chemical Name:(3R,5S,5aR,8aS)-5-[2-(4-methoxyphenylmethyloxy)ethyl]-3-phenylhexahydro-1,4-dioxa-3a-azacyclopenta[c]pentalene
CAS No.:845276-46-2
Molecular Formula:C₂₄H₂₉NO₄
Molecular Weight:395.499
Hs Code.:

Synonyms:(3R,5S,5aR,8aS)-5-[2-(4-methoxyphenylmethyloxy)ethyl]-3-phenylhexahydro-1,4-dioxa-3a-azacyclopenta[c]pentalene

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Chemical Property of (3R,5S,5aR,8aS)-5-[2-(4-methoxyphenylmethyloxy)ethyl]-3-phenylhexahydro-1,4-dioxa-3a-azacyclopenta[c]pentalene

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Technology Process of (3R,5S,5aR,8aS)-5-[2-(4-methoxyphenylmethyloxy)ethyl]-3-phenylhexahydro-1,4-dioxa-3a-azacyclopenta[c]pentalene

There total 6 articles about (3R,5S,5aR,8aS)-5-[2-(4-methoxyphenylmethyloxy)ethyl]-3-phenylhexahydro-1,4-dioxa-3a-azacyclopenta[c]pentalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 845276-46-2
(3R,5S,5aR,8aS)-5-[2-(4-methoxyphenylmethyloxy)ethyl]-3-phenylhexahydro-1,4-dioxa-3a-azacyclopenta[c]pentalene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 91 percent / NaH / tetrahydrofuran; dimethylformamide

2.1: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

2.2: tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 25 °C

3.1: H₂; pyridine / Pd/BaSO₄ / methanol / 25 °C / 760 Torr

4.1: toluene / 45 °C

5.1: toluene / 18 h / 75 °C

With pyridine; n-butyllithium; hydrogen; sodium hydride; Pd-BaSO₄; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2004-836049

Reference yield:

: 218434-90-3
1-but-3-ynyloxymethyl-4-methoxy-benzene

: 845276-46-2
(3R,5S,5aR,8aS)-5-[2-(4-methoxyphenylmethyloxy)ethyl]-3-phenylhexahydro-1,4-dioxa-3a-azacyclopenta[c]pentalene

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

1.2: tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 25 °C

2.1: H₂; pyridine / Pd/BaSO₄ / methanol / 25 °C / 760 Torr

3.1: toluene / 45 °C

4.1: toluene / 18 h / 75 °C

With pyridine; n-butyllithium; hydrogen; Pd-BaSO₄; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene;
DOI:10.1055/s-2004-836049

Reference yield:

: 845276-44-0
8-[4-methoxyphenylmethyloxy]-1,1,1-trimethoxy-5-octyne

: 845276-46-2
(3R,5S,5aR,8aS)-5-[2-(4-methoxyphenylmethyloxy)ethyl]-3-phenylhexahydro-1,4-dioxa-3a-azacyclopenta[c]pentalene

Guidance literature:: Multi-step reaction with 3 steps

1: H₂; pyridine / Pd/BaSO₄ / methanol / 25 °C / 760 Torr

2: toluene / 45 °C

3: toluene / 18 h / 75 °C

With pyridine; hydrogen; Pd-BaSO₄; In methanol; toluene;
DOI:10.1055/s-2004-836049