(4R,5R)-2-((1S,2R,3R,4R)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane

Base Information

Chemical Name:(4R,5R)-2-((1S,2R,3R,4R)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane
CAS No.:816454-29-2
Molecular Formula:C₂₉H₂₈O₂
Molecular Weight:408.54
Hs Code.:

Synonyms:(4R,5R)-2-((1S,2R,3R,4R)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane

Suppliers and Price of (4R,5R)-2-((1S,2R,3R,4R)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5R)-2-((1S,2R,3R,4R)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Useful:

Technology Process of (4R,5R)-2-((1S,2R,3R,4R)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane

There total 7 articles about (4R,5R)-2-((1S,2R,3R,4R)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 816454-13-4,816454-36-1
2-exo-methyl-3-endo-phenylnorbornene-2-carbaldehyde

: 52340-78-0
(R,R)-hydroxybenzoin

: 816454-29-2
(4R,5R)-2-((1S,2R,3R,4R)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane

: 816454-23-6
(1S,2R,3S,4R,5R,6R)-5-Bromo-6-((1R,2R)-2-hydroxy-1,2-diphenyl-ethoxy)-2-methyl-3-phenyl-bicyclo[2.2.1]heptane-2-carbaldehyde

Guidance literature:: 2-exo-methyl-3-endo-phenylnorbornene-2-carbaldehyde; (R,R)-hydroxybenzoin; With toluene-4-sulfonic acid; In toluene; at 20 ℃; for 3h;

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 20h;
DOI:10.1002/chem.200400444

Reference yield:

: 816454-13-4,816454-36-1
2-exo-methyl-3-endo-phenylnorbornene-2-carbaldehyde

: 52340-78-0
(R,R)-hydroxybenzoin

: (4R,5R)-2-((1R,2S,3S,4S)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane

: 816454-29-2
(4R,5R)-2-((1S,2R,3R,4R)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 20 ℃; for 3h; Title compound not separated from byproducts;
DOI:10.1002/chem.200400444

Reference yield:

: methyl 3-phenylnorbornene-2-carboxylate

: 816454-29-2
(4R,5R)-2-((1S,2R,3R,4R)-2-Methyl-3-phenyl-bicyclo[2.2.1]hept-5-en-2-yl)-4,5-diphenyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 76 percent / tetrahydrofuran / 12 h / 20 °C

2.1: 97 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

3.1: 95 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

4.1: p-TsOH / toluene / 3 h / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; toluene; 3.1: Swern oxidation;
DOI:10.1002/chem.200400444