2S-(2-amino-5-cyano-6methylsulfanyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide

Base Information

Chemical Name:2S-(2-amino-5-cyano-6methylsulfanyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide
CAS No.:851333-72-7
Molecular Formula:C₁₆H₁₅F₃N₆OS
Molecular Weight:396.396
Hs Code.:

Synonyms:2S-(2-amino-5-cyano-6methylsulfanyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2S-(2-amino-5-cyano-6methylsulfanyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide

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Technology Process of 2S-(2-amino-5-cyano-6methylsulfanyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide

There total 1 articles about 2S-(2-amino-5-cyano-6methylsulfanyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 851335-82-5
2-amino-4-methanesulfinyl-6-methylsulfanyl-pyrimidine-5-carbonitrile

: S-2-amino-N-(3-trifluoromethyl-phenyl)-propionamide

: 851333-72-7
2S-(2-amino-5-cyano-6methylsulfanyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 3h;

Reference yield:

: 851333-72-7
2S-(2-amino-5-cyano-6methylsulfanyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide

: 851334-00-4
C₁₆H₁₅F₃N₆O₂S

: 851334-02-6
2S-(2-amino-5-cyano-6methylsulfonyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 851333-72-7
2S-(2-amino-5-cyano-6methylsulfanyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide

: 851334-08-2
2S-(2-amino-5-cyano-6-methoxy-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C

2: sodium methylate / acetonitrile / 0.25 h

With sodium methylate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;