Technology Process of (R,E)-11-(3,5-dimethoxyphenyl)-2,8-dimethylundec-8-en-3-yne-2,5-diol
There total 4 articles about (R,E)-11-(3,5-dimethoxyphenyl)-2,8-dimethylundec-8-en-3-yne-2,5-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine;
In
toluene;
at 23 ℃;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja204142n
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dilithium tetrachlorocuprate / tetrahydrofuran / 2.17 h / 0 °C / Inert atmosphere
2: sodium periodate; periodic acid dihydrate / tetrahydrofuran; water / 0 - 23 °C / Inert atmosphere
3: (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine / toluene / 23 °C / Inert atmosphere
With
sodium periodate; periodic acid dihydrate; dilithium tetrachlorocuprate; (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine;
In
tetrahydrofuran; water; toluene;
DOI:10.1021/ja204142n
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium periodate; periodic acid dihydrate / tetrahydrofuran; water / 0 - 23 °C / Inert atmosphere
2: (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine / toluene / 23 °C / Inert atmosphere
With
sodium periodate; periodic acid dihydrate; (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine;
In
tetrahydrofuran; water; toluene;
DOI:10.1021/ja204142n
