3-(4-fluorophenyl)-1-methyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)urea

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Chemical Name:3-(4-fluorophenyl)-1-methyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)urea
CAS No.:1610610-63-3
Molecular Formula:C₂₂H₁₆F₄N₄O
Molecular Weight:428.389
Hs Code.:

Synonyms:3-(4-fluorophenyl)-1-methyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)urea

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Chemical Property of 3-(4-fluorophenyl)-1-methyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)urea

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Technology Process of 3-(4-fluorophenyl)-1-methyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)urea

There total 7 articles about 3-(4-fluorophenyl)-1-methyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610612-16-2
N-methyl-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-amine

: 1195-45-5
para-fluorophenyl isocyanate

: 1610610-63-3
3-(4-fluorophenyl)-1-methyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)urea

Guidance literature:: N-methyl-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-amine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

para-fluorophenyl isocyanate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1610611-83-0
3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxylic acid

: 1610610-63-3
3-(4-fluorophenyl)-1-methyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenyl phosphoryl azide / toluene / 12 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 4 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 4 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; toluene; 1.1: |Curtius Rearrangement;

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1610610-63-3
3-(4-fluorophenyl)-1-methyl-1-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: O-(2,4-dinitrophenyl)hydroxylamine / N,N-dimethyl-formamide / 40 °C

1.2: 100 °C

2.1: water; sodium hydroxide / methanol; 1,4-dioxane / 3 h / 20 °C

3.1: diphenyl phosphoryl azide / toluene / 12 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 4 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

6.2: 4 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; sodium hydride; O-(2,4-dinitrophenyl)hydroxylamine; sodium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; 3.1: |Curtius Rearrangement;