tert-butyl (3R,5S)-3-(tert-butyldimethylsilyloxy)-2-oxo-1-phenyltetradecan-5-ylcarbamate

Base Information

Chemical Name:tert-butyl (3R,5S)-3-(tert-butyldimethylsilyloxy)-2-oxo-1-phenyltetradecan-5-ylcarbamate
CAS No.:1616379-83-9
Molecular Formula:C₃₁H₅₅NO₄Si
Molecular Weight:533.867
Hs Code.:

Synonyms:tert-butyl (3R,5S)-3-(tert-butyldimethylsilyloxy)-2-oxo-1-phenyltetradecan-5-ylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (3R,5S)-3-(tert-butyldimethylsilyloxy)-2-oxo-1-phenyltetradecan-5-ylcarbamate

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Technology Process of tert-butyl (3R,5S)-3-(tert-butyldimethylsilyloxy)-2-oxo-1-phenyltetradecan-5-ylcarbamate

There total 7 articles about tert-butyl (3R,5S)-3-(tert-butyldimethylsilyloxy)-2-oxo-1-phenyltetradecan-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1616379-78-2
C₂₄H₄₇NO₄Si

: 1589-82-8
phenylmagnesium bromide

: 1616379-83-9
tert-butyl (3R,5S)-3-(tert-butyldimethylsilyloxy)-2-oxo-1-phenyltetradecan-5-ylcarbamate

Guidance literature:: In diethyl ether; at -78 - 20 ℃; for 3h;
DOI:10.1016/j.tet.2014.05.037

Reference yield:

: 1616379-54-4
(R)-N-((2R,4S)-1,2-bis(tert-butyldimethylsilyloxy)tridecan-4-yl)-2-methylpropane-2-sulfinamide

: 1616379-83-9
tert-butyl (3R,5S)-3-(tert-butyldimethylsilyloxy)-2-oxo-1-phenyltetradecan-5-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol; 1,4-dioxane / 0.5 h / 0 °C

2: triethylamine / dichloromethane

3: sarett reagent / N,N-dimethyl-formamide / 24 h / 20 °C

4: diethyl ether / 3 h / -78 - 20 °C

With hydrogenchloride; sarett reagent; triethylamine; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.05.037

Reference yield:

: 1616379-68-0
tert-butyl (2R,4S)-2-(tert-butyldimethylsilyloxy)-1-hydroxytridecan-4-ylcarbamate

: 1616379-83-9
tert-butyl (3R,5S)-3-(tert-butyldimethylsilyloxy)-2-oxo-1-phenyltetradecan-5-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sarett reagent / N,N-dimethyl-formamide / 24 h / 20 °C

2: diethyl ether / 3 h / -78 - 20 °C

With sarett reagent; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.05.037