3-tert-butoxycarbonylamino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-succinamic acid benzyl ester

Base Information

• Chemical Name: 3-tert-butoxycarbonylamino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-succinamic acid benzyl ester
• CAS No.: 145232-39-9
• Molecular Formula: C₂₆H₃₄N₂O₇
• Molecular Weight: 486.565

Synonyms:3-tert-butoxycarbonylamino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-succinamic acid benzyl ester

Chemical Property of 3-tert-butoxycarbonylamino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-succinamic acid benzyl ester

Chemical Property:

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Technology Process of 3-tert-butoxycarbonylamino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-succinamic acid benzyl ester

There total 3 articles about 3-tert-butoxycarbonylamino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester (13798-75-9) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 3-tert-butoxycarbonylamino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-succinamic acid benzyl ester (145232-39-9)

Guidance literature:

In 1,2-dimethoxyethane; at 20 ℃;

DOI:10.1021/jm000937a

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → 3-tert-butoxycarbonylamino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-succinamic acid benzyl ester (145232-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -15 °C / Inert atmosphere

2: tetrahydrofuran / 1 h / Inert atmosphere

With 4-methyl-morpholine; In tetrahydrofuran;

DOI:10.2174/157018010791163497

Reference yield:

(S)-3-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester (84890-97-1) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 3-tert-butoxycarbonylamino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-succinamic acid benzyl ester (145232-39-9)

Guidance literature:

In tetrahydrofuran; for 1h; Inert atmosphere;

DOI:10.2174/157018010791163497

upstream raw materials:

N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester

2-(3,4-dimethoxyphenyl)-ethylamine

BOC-L-aspartic acid 4-benzyl ester

(S)-3-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester

Downstream raw materials:

C₃₁H₃₆N₂O₈

C₃₁H₃₉N₃O₁₀

C₃₂H₄₁N₃O₁₀

C₃₀H₃₉N₃O₈S

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