2-(4-fluoro-2-(8-fluoro-2-naphthyloxy)phenoxy)-N-(2-methyl-4-sulfamoylphenyl)acetamide

Base Information

Chemical Name:2-(4-fluoro-2-(8-fluoro-2-naphthyloxy)phenoxy)-N-(2-methyl-4-sulfamoylphenyl)acetamide
CAS No.:1322035-78-8
Molecular Formula:C₂₅H₂₀F₂N₂O₅S
Molecular Weight:498.507
Hs Code.:

Synonyms:2-(4-fluoro-2-(8-fluoro-2-naphthyloxy)phenoxy)-N-(2-methyl-4-sulfamoylphenyl)acetamide

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Chemical Property of 2-(4-fluoro-2-(8-fluoro-2-naphthyloxy)phenoxy)-N-(2-methyl-4-sulfamoylphenyl)acetamide

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Technology Process of 2-(4-fluoro-2-(8-fluoro-2-naphthyloxy)phenoxy)-N-(2-methyl-4-sulfamoylphenyl)acetamide

There total 4 articles about 2-(4-fluoro-2-(8-fluoro-2-naphthyloxy)phenoxy)-N-(2-methyl-4-sulfamoylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 329944-57-2
N-[4-(aminosulfonyl)-2-methylphenyl]-2-bromoacetamide

: 1322036-04-3
C₁₆H₁₀F₂O₂

: 1322035-78-8
2-(4-fluoro-2-(8-fluoro-2-naphthyloxy)phenoxy)-N-(2-methyl-4-sulfamoylphenyl)acetamide

Guidance literature:: With potassium carbonate; potassium iodide; In acetone; for 15h; Reflux;
DOI:10.1016/j.bmc.2011.05.060

Reference yield:

: 1322036-24-7
C₁₇H₁₂F₂O₂

: 1322035-78-8
2-(4-fluoro-2-(8-fluoro-2-naphthyloxy)phenoxy)-N-(2-methyl-4-sulfamoylphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 12.5 h / -30 - 20 °C

2: potassium carbonate; potassium iodide / acetone / 15 h / Reflux

With boron tribromide; potassium carbonate; potassium iodide; In dichloromethane; acetone;
DOI:10.1016/j.bmc.2011.05.060

Reference yield:

: 496-69-5
2-bromo-4-fluoro-phenol

: 1322035-78-8
2-(4-fluoro-2-(8-fluoro-2-naphthyloxy)phenoxy)-N-(2-methyl-4-sulfamoylphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 6 h / Reflux

2: copper(l) iodide; potassium phosphate; (E)-1-(2-pyridinyl)methylene-2-phenylhydrazine / 1,4-dioxane / 95 - 105 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 12.5 h / -30 - 20 °C

4: potassium carbonate; potassium iodide / acetone / 15 h / Reflux

With potassium phosphate; copper(l) iodide; boron tribromide; potassium carbonate; potassium iodide; (E)-1-(2-pyridinyl)methylene-2-phenylhydrazine; In 1,4-dioxane; dichloromethane; acetone; 2: Ullmann condensation;
DOI:10.1016/j.bmc.2011.05.060