(1S,2S)-2-[2-(R_P)-(methylphenylphosphinoyl)ethylamino]-1-phenyl-propan-1-ol

Base Information

• Chemical Name: (1S,2S)-2-[2-(R_P)-(methylphenylphosphinoyl)ethylamino]-1-phenyl-propan-1-ol
• CAS No.: 883857-13-4
• Molecular Formula: C₁₈H₂₄NO₂P
• Molecular Weight: 317.368

Synonyms:(1S,2S)-2-[2-(R_P)-(methylphenylphosphinoyl)ethylamino]-1-phenyl-propan-1-ol

Chemical Property of (1S,2S)-2-[2-(R_P)-(methylphenylphosphinoyl)ethylamino]-1-phenyl-propan-1-ol

Chemical Property:

Purity/Quality:

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Technology Process of (1S,2S)-2-[2-(R_P)-(methylphenylphosphinoyl)ethylamino]-1-phenyl-propan-1-ol

There total 4 articles about (1S,2S)-2-[2-(R_P)-(methylphenylphosphinoyl)ethylamino]-1-phenyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl methylphenylphosphinate (6389-79-3) → (1S,2S)-2-[2-(RP)-(methylphenylphosphinoyl)ethylamino]-1-phenyl-propan-1-ol (883857-13-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / phosphorus pentachloride / CCl₄ / 3 h / Heating

2: pyridine / tetrahydrofuran / 0 - 20 °C

3: 80 percent / tetrahydrofuran / -78 - -40 °C

4: methanol / 80 °C

With pyridine; phosphorus pentachloride; In tetrahydrofuran; methanol; tetrachloromethane; 4: Michael addition;

DOI:10.1021/jo052575q

Reference yield:

methyl(phenyl)phosphinic chloride (5761-97-7) → (1S,2S)-2-[2-(RP)-(methylphenylphosphinoyl)ethylamino]-1-phenyl-propan-1-ol (883857-13-4)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / tetrahydrofuran / 0 - 20 °C

2: 80 percent / tetrahydrofuran / -78 - -40 °C

3: methanol / 80 °C

With pyridine; In tetrahydrofuran; methanol; 3: Michael addition;

DOI:10.1021/jo052575q

Reference yield:

(1S,2S)-2-amino-1-phenylpropanol (492-39-7,58550-13-3,757124-50-8) + (+)-(RP)-methylphenylvinylphosphine oxide (171598-25-7) → (1S,2S)-2-[2-(RP)-(methylphenylphosphinoyl)ethylamino]-1-phenyl-propan-1-ol (883857-13-4)

Guidance literature:

In methanol; at 80 ℃;

DOI:10.1021/jo052575q

upstream raw materials:

(1S,2S)-2-amino-1-phenylpropanol

(+)-(R_P)-methylphenylvinylphosphine oxide

methyl methylphenylphosphinate

methyl(phenyl)phosphinic chloride

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