(7-methoxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid benzyl ester

Base Information

• Chemical Name: (7-methoxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid benzyl ester
• CAS No.: 926888-10-0
• Molecular Formula: C₂₄H₂₁N₃O₄
• Molecular Weight: 415.448

Synonyms:(7-methoxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid benzyl ester

Chemical Property of (7-methoxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid benzyl ester

Chemical Property:

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Technology Process of (7-methoxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid benzyl ester

There total 12 articles about (7-methoxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.29%

(2-amino-5-methoxyphenyl)(phenyl)methanone (17549-79-0) + 2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine (124676-19-3) → (7-methoxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid benzyl ester (926888-10-0)

Guidance literature:

2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine; With oxalyl dichloride; In tetrahydrofuran; at 0 ℃; for 0.5h;

(2-amino-5-methoxyphenyl)(phenyl)methanone; With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

[benzotriazol-1-yl-(2-benzoyl-4-methoxy-phenylcarbamoyl)-methyl]-carbamic acid benzyl ester → (7-methoxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid benzyl ester (926888-10-0)

Guidance literature:

[benzotriazol-1-yl-(2-benzoyl-4-methoxy-phenylcarbamoyl)-methyl]-carbamic acid benzyl ester; With ammonia; In tetrahydrofuran; methanol; for 18h;

With ammonium acetate; acetic acid; at 20 ℃; for 18h;

DOI:10.1021/jm051185t

Reference yield:

(2-amino-5-methoxyphenyl)(phenyl)methanone (17549-79-0) → (7-methoxy-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid benzyl ester (926888-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-methylmorpholine / tetrahydrofuran / 0 - 20 °C

2.1: NH₃ / methanol; tetrahydrofuran / 18 h

2.2: 800 mg / NH₄OAc; AcOH / 18 h / 20 °C

With 4-methyl-morpholine; ammonia; In tetrahydrofuran; methanol;

DOI:10.1021/jm051185t

upstream raw materials:

bromobenzene

O-benzyl carbamate

(2-amino-5-methoxyphenyl)(phenyl)methanone

6-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione

Downstream raw materials:

3-amino-7-methoxy-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one

benzyl (7-methoxy-5-phenyl-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

benzyl (8-methoxy-1-methyl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate

(2R,3S)-N-((3S)-7-methoxy-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

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