ethyl 2-(4-(dimethylamino)phenyl)-1-(3-(2-oxopyrrolidin-1-yl)propyl)-1H-benzo[d]imidazole-5-carboxylate

Base Information

• Chemical Name: ethyl 2-(4-(dimethylamino)phenyl)-1-(3-(2-oxopyrrolidin-1-yl)propyl)-1H-benzo[d]imidazole-5-carboxylate
• CAS No.: 1620558-13-5
• Molecular Formula: C₂₅H₃₀N₄O₃
• Molecular Weight: 434.538
• Mol file: 1620558-13-5.mol

Synonyms:ethyl 2-(4-(dimethylamino)phenyl)-1-(3-(2-oxopyrrolidin-1-yl)propyl)-1H-benzo[d]imidazole-5-carboxylate

Chemical Property of ethyl 2-(4-(dimethylamino)phenyl)-1-(3-(2-oxopyrrolidin-1-yl)propyl)-1H-benzo[d]imidazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-(dimethylamino)phenyl)-1-(3-(2-oxopyrrolidin-1-yl)propyl)-1H-benzo[d]imidazole-5-carboxylate

There total 6 articles about ethyl 2-(4-(dimethylamino)phenyl)-1-(3-(2-oxopyrrolidin-1-yl)propyl)-1H-benzo[d]imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C16H23N3O3 (1376395-94-6) + 4-dimethylamino-benzaldehyde (100-10-7) → ethyl 2-(4-(dimethylamino)phenyl)-1-(3-(2-oxopyrrolidin-1-yl)propyl)-1H-benzo[d]imidazole-5-carboxylate (1620558-13-5)

Guidance literature:

With sodium meta bi sulfate; In water; at 20 ℃; for 2h; Green chemistry;

DOI:10.1016/j.ejmech.2014.06.060

Reference yield: 72.0%

C16H23N3O3 (1376395-94-6) + sodium 1-hydroxy-1-(4-dimethylaminophenyl)methanesulfonate (101306-91-6) → ethyl 2-(4-(dimethylamino)phenyl)-1-(3-(2-oxopyrrolidin-1-yl)propyl)-1H-benzo[d]imidazole-5-carboxylate (1620558-13-5)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.06.025

Reference yield:

ethyl 4-fluoro-3-nitrobenzoate (367-80-6) → ethyl 2-(4-(dimethylamino)phenyl)-1-(3-(2-oxopyrrolidin-1-yl)propyl)-1H-benzo[d]imidazole-5-carboxylate (1620558-13-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 1 h / 20 °C

2: ammonium formate; palladium 10% on activated carbon / ethanol / 20 °C

3: sodium meta bi sulfate / water / 2 h / 20 °C / Green chemistry

With sodium meta bi sulfate; palladium 10% on activated carbon; ammonium formate; In ethanol; water;

DOI:10.1016/j.ejmech.2014.06.060

upstream raw materials:

ethyl 4-fluoro-3-nitrobenzoate

3-nitro-4-fluorobenzoic acid

Ethyl 4-(3-(2-oxopyrrolidin-1-yl)propylamino)-3-nitrobenzoate

C₁₆H₂₃N₃O₃