(S)-2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]propionamide

Base Information

Chemical Name:(S)-2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]propionamide
CAS No.:1590397-14-0
Molecular Formula:C₂₄H₂₄F₄N₄O₃S
Molecular Weight:524.539
Hs Code.:

Synonyms:(S)-2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]propionamide

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Chemical Property of (S)-2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]propionamide

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Technology Process of (S)-2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]propionamide

There total 4 articles about (S)-2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1590398-41-6
(S)-2-(4-fluoro-N-isopropylphenylsulfonamido)propanoic acid

: 1257437-46-9
[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]methylamine

: 1590397-14-0
(S)-2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]propionamide

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1590397-14-0
(S)-2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water; ethanol / 7 h / 130 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 2 h / 0 °C

3: palladium 10% on activated carbon; hydrogen / 3 h / 2585.81 Torr

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h

With 1,4-diaza-bicyclo[2.2.2]octane; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; sodium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 1: |Suzuki Coupling;

Reference yield:

: 1257437-45-8
6-(4-(trifluoromethyl)phenyl)pyrimidine-4-carbonitrile

: 1590397-14-0
(S)-2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / 3 h / 2585.81 Torr

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;