(R)-4-{(E)-3-[(2S,4R)-4-(4-tert-Butyl-phenyl)-2-((S)-1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-pyrrolidin-1-yl]-propenyl}-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (R)-4-{(E)-3-[(2S,4R)-4-(4-tert-Butyl-phenyl)-2-((S)-1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-pyrrolidin-1-yl]-propenyl}-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester
• CAS No.: 1026536-24-2
• Molecular Formula: C₃₄H₅₃N₃O₅S₂
• Molecular Weight: 647.944
• Mol file: 1026536-24-2.mol

Synonyms:(R)-4-{(E)-3-[(2S,4R)-4-(4-tert-Butyl-phenyl)-2-((S)-1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-pyrrolidin-1-yl]-propenyl}-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester

Chemical Property of (R)-4-{(E)-3-[(2S,4R)-4-(4-tert-Butyl-phenyl)-2-((S)-1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-pyrrolidin-1-yl]-propenyl}-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-{(E)-3-[(2S,4R)-4-(4-tert-Butyl-phenyl)-2-((S)-1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-pyrrolidin-1-yl]-propenyl}-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester

There total 8 articles about (R)-4-{(E)-3-[(2S,4R)-4-(4-tert-Butyl-phenyl)-2-((S)-1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-pyrrolidin-1-yl]-propenyl}-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(R)-4-((E)-3-Bromo-propenyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester (245420-31-9) + (S)-2-{[(2S,4R)-4-(4-tert-Butyl-phenyl)-pyrrolidine-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester; compound with trifluoro-acetic acid → (R)-4-{(E)-3-[(2S,4R)-4-(4-tert-Butyl-phenyl)-2-((S)-1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-pyrrolidin-1-yl]-propenyl}-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester (1026536-24-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; In dimethyl sulfoxide;

DOI:10.1248/cpb.48.740

Reference yield:

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate (74844-91-0) → (R)-4-{(E)-3-[(2S,4R)-4-(4-tert-Butyl-phenyl)-2-((S)-1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-pyrrolidin-1-yl]-propenyl}-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester (1026536-24-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 100 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

2.1: LiN[Si(CH₃)3]2 / tetrahydrofuran / -78 °C

2.2: 30 percent / tetrahydrofuran / -78 - 20 °C

3.1: (PhCH₂)(Cl)Pd(PPh₃)2; LiCl; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 86 °C

4.1: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate

5.1: aq. LiOH / dioxane / 0 - 20 °C

6.1: 94 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt*H₂O; N-methylmorpholine / dimethylformamide

7.1: 100 percent / Et₃SiH / CH₂Cl₂ / 0 °C

8.1: 70 percent / NaI; iPr₂NEt / dimethylsulfoxide

With 4-methyl-morpholine; triethylsilane; lithium hydroxide; oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); hydrogen; sodium carbonate; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium chloride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1.1: Oxidation / 2.1: Enolization / 2.2: Triflation / 3.1: Arylation / 4.1: Catalytic hydrogenation / 5.1: Hydrolysis / 6.1: Acylation / 7.1: Acidolysis / 8.1: Alkylation;

DOI:10.1248/cpb.48.740

Reference yield:

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate (102195-80-2) → (R)-4-{(E)-3-[(2S,4R)-4-(4-tert-Butyl-phenyl)-2-((S)-1-methoxycarbonyl-3-methylsulfanyl-propylcarbamoyl)-pyrrolidin-1-yl]-propenyl}-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester (1026536-24-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: LiN[Si(CH₃)3]2 / tetrahydrofuran / -78 °C

1.2: 30 percent / tetrahydrofuran / -78 - 20 °C

2.1: (PhCH₂)(Cl)Pd(PPh₃)2; LiCl; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 86 °C

3.1: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate

4.1: aq. LiOH / dioxane / 0 - 20 °C

5.1: 94 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt*H₂O; N-methylmorpholine / dimethylformamide

6.1: 100 percent / Et₃SiH / CH₂Cl₂ / 0 °C

7.1: 70 percent / NaI; iPr₂NEt / dimethylsulfoxide

With 4-methyl-morpholine; triethylsilane; lithium hydroxide; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium chloride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1.1: Enolization / 1.2: Triflation / 2.1: Arylation / 3.1: Catalytic hydrogenation / 4.1: Hydrolysis / 5.1: Acylation / 6.1: Acidolysis / 7.1: Alkylation;

DOI:10.1248/cpb.48.740

upstream raw materials:

(R)-4-((E)-3-Bromo-propenyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

1-tert-butyl 2-methyl (2S)-4-(trifluoromethanesulfonyloxy)-2,3-dihydropyrrole-1,2-dicarboxylate

Downstream raw materials:

C₃₃H₅₁N₃O₇S₃

C₃₂H₄₉N₃O₇S₃