ethyl 2-(3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzamido)acetate

Base Information

Chemical Name:ethyl 2-(3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzamido)acetate
CAS No.:1210908-26-1
Molecular Formula:C₁₈H₁₈F₃N₃O₃
Molecular Weight:381.354
Hs Code.:

Synonyms:ethyl 2-(3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzamido)acetate

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Chemical Property of ethyl 2-(3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzamido)acetate

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Technology Process of ethyl 2-(3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzamido)acetate

There total 1 articles about ethyl 2-(3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1210909-03-7
3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzoic acid

: 623-33-6
glycine ethyl ester hydrochloride

: 1210908-26-1
ethyl 2-(3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzamido)acetate

Guidance literature:: 3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 0.5h;

glycine ethyl ester hydrochloride; With triethylamine; In acetonitrile; at 20 ℃; for 4h;
DOI:10.1021/jm901891p

Reference yield: 88.0%

: 1210908-26-1
ethyl 2-(3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzamido)acetate

: 1210908-30-7
2-(3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzamido)acetic acid

Guidance literature:: ethyl 2-(3-methyl-4-(2-(trifluoromethyl)pyridin-4-ylamino)benzamido)acetate; With water; sodium hydroxide; In ethanol; at 20 ℃; for 24h;

With hydrogenchloride; In water; pH=3 - 4; Cooling with ice;
DOI:10.1021/jm901891p