N-(((chloromethyl)dimethylgermyl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(((chloromethyl)dimethylgermyl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide
• CAS No.: 1622406-92-1
• Molecular Formula: C₁₇H₂₁ClGeINO₂S
• Molecular Weight: 538.373
• Mol file: 1622406-92-1.mol

Synonyms:N-(((chloromethyl)dimethylgermyl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

Chemical Property of N-(((chloromethyl)dimethylgermyl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N-(((chloromethyl)dimethylgermyl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

There total 1 articles about N-(((chloromethyl)dimethylgermyl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-tosyl-2-iodoaniline (61613-20-5) + bis(chloromethyl)dimethylgermanium (21581-91-9) → N-(((chloromethyl)dimethylgermyl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide (1622406-92-1)

Guidance literature:

N-tosyl-2-iodoaniline; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.0833333h; Inert atmosphere;

bis(chloromethyl)dimethylgermanium; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; Inert atmosphere;

DOI:10.1002/chem.201402597

Reference yield:

N-(((chloromethyl)dimethylgermyl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide (1622406-92-1) → 3,3-dimethyl-1-tosyl-1,2,3,4-tetrahydrobenzo[e][1,3]azagermine (1622407-02-6) + 4,4-dimethyl-1-tosyl-1,2,3,4-tetrahydrobenzo[b][1,4]azagermine (1622407-27-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -40 ℃; for 1h; Overall yield = 62 %; Overall yield = 81 mg; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201402597

upstream raw materials:

N-tosyl-2-iodoaniline

bis(chloromethyl)dimethylgermanium

Downstream raw materials:

3,3-dimethyl-1-tosyl-1,2,3,4-tetrahydrobenzo[e][1,3]azagermine

4,4-dimethyl-1-tosyl-1,2,3,4-tetrahydrobenzo[b][1,4]azagermine