N₁-[3-({[2-chloro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride

Base Information

• Chemical Name: N₁-[3-({[2-chloro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride
• CAS No.: 953392-25-1
• Molecular Formula: C₂₂H₂₄ClN₃O₅S*ClH
• Molecular Weight: 514.43

Synonyms:N₁-[3-({[2-chloro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride

Chemical Property of N₁-[3-({[2-chloro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of N₁-[3-({[2-chloro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride

There total 4 articles about N₁-[3-({[2-chloro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N1-[3-{[(4-bromo-2-chlorophenyl)sulfonyl]amino}-4-(methyloxy)phenyl]-2-methylalaninamide (953391-75-8) + 4,4,5,5-tetramethyl-2-(5-methylfuran-2-yl)-1,3,2-dioxaborolane (338998-93-9) → N1-[3-({[2-chloro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride (953392-25-1)

Guidance literature:

N₁-[3-{[(4-bromo-2-chlorophenyl)sulfonyl]amino}-4-(methyloxy)phenyl]-2-methylalaninamide; 4,4,5,5-tetramethyl-2-(5-methylfuran-2-yl)-1,3,2-dioxaborolane; With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.333333h; Microwave irradiation;

With hydrogenchloride; In methanol; diethyl ether; dichloromethane;

Reference yield:

N-[5-amino-2-(methyloxy)phenyl]-4-bromo-2-chlorobenzenesulfonamide (953391-74-7) → N1-[3-({[2-chloro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride (953392-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation

With pyridine; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

4-bromo-2-chlorobenzene-1-sulfonyl chloride (351003-52-6) → N1-[3-({[2-chloro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-4-(methyloxy)phenyl]-2-methylalaninamide hydrochloride (953392-25-1)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 20 °C

2: ammonium formate / 5 % platinum on carbon / methanol; water / 40 h / 20 °C

3: pyridine / dichloromethane / 20 °C

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation

With pyridine; ammonium formate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; 5 % platinum on carbon; In methanol; 1,2-dimethoxyethane; dichloromethane; water;

upstream raw materials:

N₁-[3-{[(4-bromo-2-chlorophenyl)sulfonyl]amino}-4-(methyloxy)phenyl]-2-methylalaninamide

4,4,5,5-tetramethyl-2-(5-methylfuran-2-yl)-1,3,2-dioxaborolane

N-[5-amino-2-(methyloxy)phenyl]-4-bromo-2-chlorobenzenesulfonamide

4-bromo-2-chlorobenzene-1-sulfonyl chloride

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