ethyl 2-[N-(mesitylacetyl)-N-(methoxy)]amino-2-methylpropanoate

Base Information

• Chemical Name: ethyl 2-[N-(mesitylacetyl)-N-(methoxy)]amino-2-methylpropanoate
• CAS No.: 306950-79-8
• Molecular Formula: C₁₈H₂₇NO₄
• Molecular Weight: 321.417
• Mol file: 306950-79-8.mol

Synonyms:ethyl 2-[N-(mesitylacetyl)-N-(methoxy)]amino-2-methylpropanoate

Chemical Property of ethyl 2-[N-(mesitylacetyl)-N-(methoxy)]amino-2-methylpropanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 2-[N-(mesitylacetyl)-N-(methoxy)]amino-2-methylpropanoate

There total 2 articles about ethyl 2-[N-(mesitylacetyl)-N-(methoxy)]amino-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(2,4,6-trimethyl-phenyl)acetyl chloride (52629-46-6) + ethyl 2-(methoxy)amino-2-methylpropionate (306950-80-1) → ethyl 2-[N-(mesitylacetyl)-N-(methoxy)]amino-2-methylpropanoate (306950-79-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.3987/COM-02-9467

Reference yield:

ethyl 2-bromoisobutyrate (600-00-0) → ethyl 2-[N-(mesitylacetyl)-N-(methoxy)]amino-2-methylpropanoate (306950-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / methanol

2: 41 percent / 4-dimethylaminopyridine; Et₃N / CH₂Cl₂ / 1 h / 0 °C

With dmap; triethylamine; In methanol; dichloromethane;

Reference yield: 32.0%

ethyl 2-[N-(mesitylacetyl)-N-(methoxy)]amino-2-methylpropanoate (306950-79-8) → 4-hydroxy-3-mesityl-1-methoxy-5,5-dimethyl-1,5-dihydro-2H-pyrrol-2-one

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.3987/COM-02-9467

upstream raw materials:

(2,4,6-trimethyl-phenyl)acetyl chloride

ethyl 2-(methoxy)amino-2-methylpropionate

ethyl 2-bromoisobutyrate