ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-4-oxo-5-(phenylthio)-3-quinolinecarboxylate

Base Information

Chemical Name:ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-4-oxo-5-(phenylthio)-3-quinolinecarboxylate
CAS No.:123942-22-3
Molecular Formula:C₂₈H₂₄F₂N₂O₃S
Molecular Weight:506.573
Hs Code.:

Synonyms:ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-4-oxo-5-(phenylthio)-3-quinolinecarboxylate

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Chemical Property of ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-4-oxo-5-(phenylthio)-3-quinolinecarboxylate

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Technology Process of ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-4-oxo-5-(phenylthio)-3-quinolinecarboxylate

There total 8 articles about ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-4-oxo-5-(phenylthio)-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108-98-5
thiophenol

: 123942-10-9
ethyl 1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylate

: 2,6-dimethyl-4-pyridinyl

: 123942-22-3
ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-4-oxo-5-(phenylthio)-3-quinolinecarboxylate

Guidance literature:: In tetrahydrofuran;

Reference yield: 76.0%

: 108-98-5
thiophenol

: 123942-10-9
ethyl 1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylate

: 123942-22-3
ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-4-oxo-5-(phenylthio)-3-quinolinecarboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm00014a005

Reference yield:

: 4707-24-8
4-bromotetrafluorobenzenecarboxylic acid

: 123942-22-3
ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-4-oxo-5-(phenylthio)-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: PCl₅

2: 86 percent / BuLi

3: tetrahydrofuran / Ambient temperature

4: tetrahydrofuran / 1 h

5: 62 percent / K₂CO₃ / dimethylformamide / 1.5 h / 150 °C

6: 43 percent / HMPA, PdCl₂(PPh₃)2 / tetrahydrofuran / 24 h / Heating

7: 76 percent / NaH / tetrahydrofuran

With N,N,N,N,N,N-hexamethylphosphoric triamide; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; phosphorus pentachloride; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00014a005