(S)-N-(4-fluorophenyl)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-4-methylenepyrrolidine-2-carboxamide

Base Information

Chemical Name:(S)-N-(4-fluorophenyl)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-4-methylenepyrrolidine-2-carboxamide
CAS No.:1256162-67-0
Molecular Formula:C₂₀H₂₆FN₃O₄
Molecular Weight:391.443
Hs Code.:

Synonyms:(S)-N-(4-fluorophenyl)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-4-methylenepyrrolidine-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(4-fluorophenyl)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-4-methylenepyrrolidine-2-carboxamide

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Technology Process of (S)-N-(4-fluorophenyl)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-4-methylenepyrrolidine-2-carboxamide

There total 14 articles about (S)-N-(4-fluorophenyl)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-4-methylenepyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1256162-66-9
C₂₈H₃₄FN₃O₅

: 1256162-67-0
(S)-N-(4-fluorophenyl)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-4-methylenepyrrolidine-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2014.07.106

Reference yield:

: 1256162-57-8
C₂₂H₃₀N₂O₆

: 1256162-67-0
(S)-N-(4-fluorophenyl)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-4-methylenepyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 16 h / 0 - 25 °C

2: trifluoroacetic acid / dichloromethane

With chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2010.11.102

Reference yield:

: 1256162-56-7
C₂₃H₃₂N₂O₆

: 1256162-67-0
(S)-N-(4-fluorophenyl)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-4-methylenepyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / 1,4-dioxane / 5 h / 25 °C

2: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 16 h / 0 - 25 °C

3: trifluoroacetic acid / dichloromethane

With water; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2010.11.102