Technology Process of 4-{8-[(3,3,7-trimethyl-2,3-dihydro-1-benzofuran-5-yl)methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate
There total 4 articles about 4-{8-[(3,3,7-trimethyl-2,3-dihydro-1-benzofuran-5-yl)methyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,3,7-trimethyl-2,3-dihydro-1-benzofuran-5-carbaldehyde; 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoic acid;
With
sodium tris(acetoxy)borohydride; acetic acid;
In
dimethyl sulfoxide;
at 50 ℃;
trifluoroacetic acid;
In
water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetraethylammonium chloride; sodium formate; potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 75 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / -78 °C / Inert atmosphere
2.2: 20 °C
3.1: acetic acid; sodium tris(acetoxy)borohydride / dimethyl sulfoxide / 50 °C
With
n-butyllithium; tetraethylammonium chloride; sodium formate; potassium acetate; sodium tris(acetoxy)borohydride; acetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; hexanes; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 70 °C
2.1: tetraethylammonium chloride; sodium formate; potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 75 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / -78 °C / Inert atmosphere
3.2: 20 °C
4.1: acetic acid; sodium tris(acetoxy)borohydride / dimethyl sulfoxide / 50 °C
With
n-butyllithium; tetraethylammonium chloride; sodium formate; potassium acetate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; hexanes; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
