(R)-methyl 7-benzyl-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate

Base Information

• Chemical Name: (R)-methyl 7-benzyl-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate
• CAS No.: 1257337-57-7
• Molecular Formula: C₂₂H₁₉NO₃S
• Molecular Weight: 377.464

Synonyms:(R)-methyl 7-benzyl-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate

Chemical Property of (R)-methyl 7-benzyl-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate

Chemical Property:

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Technology Process of (R)-methyl 7-benzyl-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate

There total 1 articles about (R)-methyl 7-benzyl-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-(1-hydroxy-2-phenylethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (66696-84-2) + (4R)-2-benzyl-4,5-dihydrothiazole-4-carboxylic acid methyl ester (341027-48-3) → (R)-methyl 7-benzyl-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate (1257337-57-7)

Guidance literature:

With trifluoroacetic acid; In 1,2-dichloro-ethane; at 125 ℃; for 0.05h; Microwave irradiation;

DOI:10.1002/ejoc.201000796

Reference yield: 76.0%

(R)-methyl 7-benzyl-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate (1257337-57-7) + Vilsmeier reagent (3724-43-4,149409-22-3) → (R)-methyl 7-benzyl-6-formyl-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate (1257337-62-4)

Guidance literature:

In acetonitrile; Reflux;

DOI:10.1002/ejoc.201000796

upstream raw materials:

5-(1-hydroxy-2-phenylethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

(4R)-2-benzyl-4,5-dihydrothiazole-4-carboxylic acid methyl ester

Downstream raw materials:

(R)-methyl 7-benzyl-6-formyl-2,3-dihydro-5-oxo-8-phenylthiazolo[3,2-a]pyridine-3-carboxylate

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