4'-bromo-biphenyl-4-sulfonic acid (3-hydroxymethyl-2-chloro-phenyl)-amide

Base Information

Chemical Name:4'-bromo-biphenyl-4-sulfonic acid (3-hydroxymethyl-2-chloro-phenyl)-amide
CAS No.:1062213-20-0
Molecular Formula:C₁₉H₁₅BrClNO₃S
Molecular Weight:452.756
Hs Code.:

Synonyms:4'-bromo-biphenyl-4-sulfonic acid (3-hydroxymethyl-2-chloro-phenyl)-amide

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Chemical Property of 4'-bromo-biphenyl-4-sulfonic acid (3-hydroxymethyl-2-chloro-phenyl)-amide

Chemical Property:

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Technology Process of 4'-bromo-biphenyl-4-sulfonic acid (3-hydroxymethyl-2-chloro-phenyl)-amide

There total 5 articles about 4'-bromo-biphenyl-4-sulfonic acid (3-hydroxymethyl-2-chloro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₁₇BrClNO₄S

: 1062213-20-0
4'-bromo-biphenyl-4-sulfonic acid (3-hydroxymethyl-2-chloro-phenyl)-amide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 50 ℃; for 6h;
DOI:10.1016/j.bmcl.2012.11.067

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1062213-20-0
4'-bromo-biphenyl-4-sulfonic acid (3-hydroxymethyl-2-chloro-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 3 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 3 h / Reflux; Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 - 50 °C

With pyridine; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; ethanol; dichloromethane; toluene; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.11.067

Reference yield:

: 1261671-67-3
ethyl 3-amino-2-chlorobenzoate

: 1062213-20-0
4'-bromo-biphenyl-4-sulfonic acid (3-hydroxymethyl-2-chloro-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 3 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 3 h / Reflux; Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 - 50 °C

With pyridine; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; ethanol; dichloromethane; toluene; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.11.067