3-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propyl 5-chloro-2,4-dihydroxybenzoate

Base Information

Chemical Name:3-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propyl 5-chloro-2,4-dihydroxybenzoate
CAS No.:913622-14-7
Molecular Formula:C₂₁H₂₄ClNO₁₁
Molecular Weight:501.875
Hs Code.:

Synonyms:3-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propyl 5-chloro-2,4-dihydroxybenzoate

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Chemical Property of 3-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propyl 5-chloro-2,4-dihydroxybenzoate

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Technology Process of 3-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propyl 5-chloro-2,4-dihydroxybenzoate

There total 6 articles about 3-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propyl 5-chloro-2,4-dihydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 913622-10-3
3-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propan-1-ol

: 67828-44-8
5-chloro-2,4-dihydroxy-benzoic acid

: 913622-14-7
3-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propyl 5-chloro-2,4-dihydroxybenzoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; at 50 ℃; for 12h;
DOI:10.1021/jo061054f

Reference yield:

: 913622-68-1
ethyl 3-(2-methoxy-3,6-bis(methoxymethoxy)phenyl)acrylate

: 913622-14-7
3-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propyl 5-chloro-2,4-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / Pd/C / ethyl acetate / 12 h

1.2: 3.69 g / DIBAL-H / CH₂Cl₂ / 1 h / 0 °C

2.1: NH₄NO₃; (CF₃CO)2O / acetonitrile / 0.25 h / 20 °C

2.2: 67 percent / LiOH / tetrahydrofuran; methanol; H₂O / 0.08 h

3.1: 56 percent / DMAP; DCC / dimethylformamide; tetrahydrofuran / 12 h / 50 °C

With ammonium nitrate; dmap; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo061054f

Reference yield:

: 824-46-4
methoxyhydroquinone

: 913622-14-7
3-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propyl 5-chloro-2,4-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / NaH

2.1: TMEDA; n-BuLi / tetrahydrofuran / 4 h / 20 °C

2.2: 77 percent / tetrahydrofuran / 2 h

3.1: NaH / toluene / 0.25 h / 20 °C

3.2: 86 percent / toluene / 12 h / 20 °C

4.1: H₂ / Pd/C / ethyl acetate / 12 h

4.2: 3.69 g / DIBAL-H / CH₂Cl₂ / 1 h / 0 °C

5.1: NH₄NO₃; (CF₃CO)2O / acetonitrile / 0.25 h / 20 °C

5.2: 67 percent / LiOH / tetrahydrofuran; methanol; H₂O / 0.08 h

6.1: 56 percent / DMAP; DCC / dimethylformamide; tetrahydrofuran / 12 h / 50 °C

With ammonium nitrate; dmap; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; sodium hydride; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo061054f