2-[2-(2-iodophenyl)2-oxoethyl]-5-methyl-1-methylenecyclohept-4-ene

Base Information

• Chemical Name: 2-[2-(2-iodophenyl)2-oxoethyl]-5-methyl-1-methylenecyclohept-4-ene
• CAS No.: 146563-06-6
• Molecular Formula: C₁₇H₁₉IO
• Molecular Weight: 366.242
• Mol file: 146563-06-6.mol

Synonyms:2-[2-(2-iodophenyl)2-oxoethyl]-5-methyl-1-methylenecyclohept-4-ene

Chemical Property of 2-[2-(2-iodophenyl)2-oxoethyl]-5-methyl-1-methylenecyclohept-4-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(2-iodophenyl)2-oxoethyl]-5-methyl-1-methylenecyclohept-4-ene

There total 14 articles about 2-[2-(2-iodophenyl)2-oxoethyl]-5-methyl-1-methylenecyclohept-4-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-[2-hydroxy-2-(2-iodophenyl)ethyl]-5-methyl-1-methylenecyclohept-4-ene (146563-24-8) → 2-[2-(2-iodophenyl)2-oxoethyl]-5-methyl-1-methylenecyclohept-4-ene (146563-06-6)

Guidance literature:

With sodium acetate; pyridinium chlorochromate; In dichloromethane; for 14h; Ambient temperature;

DOI:10.1021/ja972427k

Reference yield:

tert-Butyl-[1-(2-iodo-phenyl)-2-(4-methyl-7-methylene-cyclohept-3-enyl)-ethoxy]-dimethyl-silane (146563-23-7) → 2-[2-(2-iodophenyl)2-oxoethyl]-5-methyl-1-methylenecyclohept-4-ene (146563-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / TBAF / tetrahydrofuran / 8 h / Ambient temperature

2: 90 percent / PCC, NaOAc, 3A MS / CH₂Cl₂ / 14 h / Ambient temperature

With tetrabutyl ammonium fluoride; sodium acetate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja972427k

Reference yield:

2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-(2-iodo-phenyl)-ethyl]-5-methyl-cyclohept-4-enone (146563-05-5) → 2-[2-(2-iodophenyl)2-oxoethyl]-5-methyl-1-methylenecyclohept-4-ene (146563-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 0.5 h, 2.) 0 deg C to rt

2: 90 percent / TBAF / tetrahydrofuran / 8 h / Ambient temperature

3: 90 percent / PCC, NaOAc, 3A MS / CH₂Cl₂ / 14 h / Ambient temperature

With n-butyllithium; tetrabutyl ammonium fluoride; sodium acetate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja972427k

upstream raw materials:

2-[2-hydroxy-2-(2-iodophenyl)ethyl]-5-methyl-1-methylenecyclohept-4-ene

tert-Butyl-[1-(2-iodo-phenyl)-2-(4-methyl-7-methylene-cyclohept-3-enyl)-ethoxy]-dimethyl-silane

2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-(2-iodo-phenyl)-ethyl]-5-methyl-cyclohept-4-enone

2-iodobenzaldehyde