N(α)-[2-(2-phenylethyl)amino-5-chlorobenzoyl]-L-alanyl-D-glutamine

Base Information

• Chemical Name: N(α)-[2-(2-phenylethyl)amino-5-chlorobenzoyl]-L-alanyl-D-glutamine
• CAS No.: 1003940-56-4
• Molecular Formula: C₂₃H₂₇ClN₄O₅
• Molecular Weight: 474.944
• Mol file: 1003940-56-4.mol

Synonyms:N(α)-[2-(2-phenylethyl)amino-5-chlorobenzoyl]-L-alanyl-D-glutamine

Chemical Property of N(α)-[2-(2-phenylethyl)amino-5-chlorobenzoyl]-L-alanyl-D-glutamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N(α)-[2-(2-phenylethyl)amino-5-chlorobenzoyl]-L-alanyl-D-glutamine

There total 1 articles about N(α)-[2-(2-phenylethyl)amino-5-chlorobenzoyl]-L-alanyl-D-glutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.9%

5-chloro-2-nitrobenzoic acid (2516-95-2) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + phenylacetaldehyde (122-78-1) + (R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid (109745-15-5) → N(α)-[2-(2-phenylethyl)amino-5-chlorobenzoyl]-L-alanyl-D-glutamine (1003940-56-4)

Guidance literature:

(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid; With benzotriazol-1-ol; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 3h; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h; solid phase reaction;

5-chloro-2-nitrobenzoic acid; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; phenylacetaldehyde; Further stages;

DOI:10.1016/j.bmcl.2011.05.056

upstream raw materials:

5-chloro-2-nitrobenzoic acid

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

phenylacetaldehyde

(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid