(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-((R)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-1-methyl-pyrrolidine-3-carbonitrile

Base Information

Chemical Name:(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-((R)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-1-methyl-pyrrolidine-3-carbonitrile
CAS No.:1354692-91-3
Molecular Formula:C₂₉H₃₃Cl₂F₂N₃O₂
Molecular Weight:564.503
Hs Code.:

(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-((R)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-1-methyl-pyrrolidine-3-carbonitrile

Synonyms:(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-((R)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-1-methyl-pyrrolidine-3-carbonitrile

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Chemical Property of (2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-((R)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-1-methyl-pyrrolidine-3-carbonitrile

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Technology Process of (2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-((R)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-1-methyl-pyrrolidine-3-carbonitrile

There total 3 articles about (2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-((R)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-1-methyl-pyrrolidine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.6%

: 68832-13-3
D-prolinol

: 1354693-55-2
(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid

: 1354692-91-3
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-((R)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-1-methyl-pyrrolidine-3-carbonitrile

Guidance literature:: With HATU; In dichloromethane; at 20 - 25 ℃; for 14h;

Reference yield:

: 1354693-60-9
rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid methyl ester

: 1354692-91-3
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-((R)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-1-methyl-pyrrolidine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 0 - 20 °C

2: lithium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

3: HATU / dichloromethane / 14 h / 20 - 25 °C

With sodium tris(acetoxy)borohydride; acetic acid; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1354693-56-3
(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methylpyrrolidine-2-carboxylic acid methyl ester

: 1354692-91-3
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-((R)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-1-methyl-pyrrolidine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

2: HATU / dichloromethane / 14 h / 20 - 25 °C

With HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;