3,3-dimethyl-5-oxo-6,6-dipropylcyclohex-1-en-1-yl trifluoromethanesulfonate

Base Information

• Chemical Name: 3,3-dimethyl-5-oxo-6,6-dipropylcyclohex-1-en-1-yl trifluoromethanesulfonate
• CAS No.: 1260160-16-4
• Molecular Formula: C₁₅H₂₃F₃O₄S
• Molecular Weight: 356.406
• Mol file: 1260160-16-4.mol

Synonyms:3,3-dimethyl-5-oxo-6,6-dipropylcyclohex-1-en-1-yl trifluoromethanesulfonate

Chemical Property of 3,3-dimethyl-5-oxo-6,6-dipropylcyclohex-1-en-1-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-dimethyl-5-oxo-6,6-dipropylcyclohex-1-en-1-yl trifluoromethanesulfonate

There total 2 articles about 3,3-dimethyl-5-oxo-6,6-dipropylcyclohex-1-en-1-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

trifluoromethylsulfonic anhydride (358-23-6) + 5,5-dimethyl-2,2-dipropylcyclohexane-1,3-dione (24551-96-0) → 3,3-dimethyl-5-oxo-6,6-dipropylcyclohex-1-en-1-yl trifluoromethanesulfonate (1260160-16-4)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; In 1,2-dichloro-ethane; at 0 - 80 ℃; for 18h;

DOI:10.1021/jacs.1c11528

Reference yield:

5,5-dimethyl-2,2-diallylcyclohexane-1,3-dione (28627-36-3) → 3,3-dimethyl-5-oxo-6,6-dipropylcyclohex-1-en-1-yl trifluoromethanesulfonate (1260160-16-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 90 h / 20 °C / 760.05 Torr

2: 2,6-di-tert-butyl-4-methylpyridine / 1,2-dichloro-ethane / 18 h / 0 - 80 °C

With 2,6-di-tert-butyl-4-methylpyridine; palladium 10% on activated carbon; hydrogen; In ethanol; 1,2-dichloro-ethane;

DOI:10.1021/jacs.1c11528

Reference yield: 92.0%

3,3-dimethyl-5-oxo-6,6-dipropylcyclohex-1-en-1-yl trifluoromethanesulfonate (1260160-16-4) + phenol (108-95-2,27073-41-2) → phenyl 3,3-dimethyl-6-propylnona-4,5-dienoate (1260160-23-3)

Guidance literature:

With caesium carbonate; In N,N-dimethyl acetamide; at 23 ℃;

DOI:10.1002/anie.201004795

upstream raw materials:

5,5-dimethyl-2,2-diallylcyclohexane-1,3-dione

trifluoromethylsulfonic anhydride

5,5-dimethyl-2,2-dipropylcyclohexane-1,3-dione

Downstream raw materials:

4-aminophenyl 3,3-dimethyl-6-propylnona-4,5-dienoate

3,3-dimethyl-6-propyl-N-tosylnona-4,5-dienamide

N-hydroxy-3,3-dimethyl-N-phenyl-6-propylnona-4,5-dienamide

benzyl 3,3-dimethyl-6-propylnona-4,5-dienoate