(2-methyl-5-tert-butylphenyl) 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thia-α-D-mannoheptopyranosyl 4-nitrobenzoate

Base Information

Chemical Name:(2-methyl-5-tert-butylphenyl) 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thia-α-D-mannoheptopyranosyl 4-nitrobenzoate
CAS No.:1442422-73-2
Molecular Formula:C₄₅H₅₃NO₁₁S
Molecular Weight:815.982
Hs Code.:

Synonyms:(2-methyl-5-tert-butylphenyl) 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thia-α-D-mannoheptopyranosyl 4-nitrobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-methyl-5-tert-butylphenyl) 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thia-α-D-mannoheptopyranosyl 4-nitrobenzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2-methyl-5-tert-butylphenyl) 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thia-α-D-mannoheptopyranosyl 4-nitrobenzoate

There total 5 articles about (2-methyl-5-tert-butylphenyl) 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thia-α-D-mannoheptopyranosyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₉H₄₉F₃O₁₀S₂

: 62-23-7
4-nitro-benzoic acid

: 1442422-73-2
(2-methyl-5-tert-butylphenyl) 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thia-α-D-mannoheptopyranosyl 4-nitrobenzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2013.04.094

Reference yield:

: 1442422-49-2
(2-methyl-5-tert-butylphenyl) 2-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-D-glycero-1-thia-α-D-mannoheptopyranoside

: 1442422-73-2
(2-methyl-5-tert-butylphenyl) 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thia-α-D-mannoheptopyranosyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: di(n-butyl)tin oxide / toluene / 4 h / Inert atmosphere; Reflux

1.2: 20 °C / Inert atmosphere

2.1: 2,4,6-tri-tert-butylpyrimidine / dichloromethane / -40 - -10 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With di(n-butyl)tin oxide; caesium carbonate; 2,4,6-tri-tert-butylpyrimidine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2013.04.094

Reference yield:

: 1442422-72-1
(2-methyl-5-tert-butylphenyl) 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2'-3'-diyl)-D-glycero-1-thia-α-D-mannoheptopyranoside

: 1442422-73-2
(2-methyl-5-tert-butylphenyl) 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thia-α-D-mannoheptopyranosyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4,6-tri-tert-butylpyrimidine / dichloromethane / -40 - -10 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With caesium carbonate; 2,4,6-tri-tert-butylpyrimidine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.04.094