6-amino-5-(formylamino)-5-(4-methylbenzyl)-2-mercaptopyrimidin-4(5H)-one

Base Information

Chemical Name:6-amino-5-(formylamino)-5-(4-methylbenzyl)-2-mercaptopyrimidin-4(5H)-one
CAS No.:167497-35-0
Molecular Formula:C₁₃H₁₄N₄O₂S
Molecular Weight:290.346
Hs Code.:

Synonyms:6-amino-5-(formylamino)-5-(4-methylbenzyl)-2-mercaptopyrimidin-4(5H)-one

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Chemical Property of 6-amino-5-(formylamino)-5-(4-methylbenzyl)-2-mercaptopyrimidin-4(5H)-one

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Technology Process of 6-amino-5-(formylamino)-5-(4-methylbenzyl)-2-mercaptopyrimidin-4(5H)-one

There total 1 articles about 6-amino-5-(formylamino)-5-(4-methylbenzyl)-2-mercaptopyrimidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 17356-08-0
thiourea

: ethyl 2-cyano-2-(formylamino)-3-(4-methylphenyl)propionate

: 5,6-Diamino-2-mercapto-5-(4-methyl-benzyl)-5H-pyrimidin-4-one

: 167497-35-0
6-amino-5-(formylamino)-5-(4-methylbenzyl)-2-mercaptopyrimidin-4(5H)-one

Guidance literature:: With sodium ethanolate; In ethanol; for 10h; Ambient temperature;
DOI:10.1021/jm00018a015

Reference yield:

: 167497-35-0
6-amino-5-(formylamino)-5-(4-methylbenzyl)-2-mercaptopyrimidin-4(5H)-one

: 167497-45-2
8-(4-methylbenzyl)imidazo<1,5-a>-1,3,5-triazine-4(3H)-thione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) TMSCl, pyridine, 2.) HMDS / 1.) RT, 30 min, 2.) reflux, 10 min

2: 60 percent / 25percent aq. NH₃, Raney Ni / 0.17 h / 100 °C

3: 85 percent / 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide / xylene / 48 h / Heating

With Lawessons reagent; pyridine; ammonium hydroxide; chloro-trimethyl-silane; nickel; 1,1,1,3,3,3-hexamethyl-disilazane; In xylene;
DOI:10.1021/jm00018a015

Reference yield:

: 167497-35-0
6-amino-5-(formylamino)-5-(4-methylbenzyl)-2-mercaptopyrimidin-4(5H)-one

: 167497-47-4
4-methoxy-8-(4-methylbenzyl)imidazo<1,5-a>-1,3,5-triazine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) TMSCl, pyridine, 2.) HMDS / 1.) RT, 30 min, 2.) reflux, 10 min

2: 60 percent / 25percent aq. NH₃, Raney Ni / 0.17 h / 100 °C

3: 85 percent / 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide / xylene / 48 h / Heating

4: 60 percent / CH₃I, K₂CO₃ / 0.08 h / Ambient temperature

With Lawessons reagent; pyridine; ammonium hydroxide; chloro-trimethyl-silane; nickel; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane; methyl iodide; In xylene;
DOI:10.1021/jm00018a015