(4S)-2-Phenyl-4-[(2S,3R)-3-vinyloxiranyl]-2-oxazoline

Base Information

Chemical Name:(4S)-2-Phenyl-4-[(2S,3R)-3-vinyloxiranyl]-2-oxazoline
CAS No.:173531-24-3
Molecular Formula:C₁₃H₁₃NO₂
Molecular Weight:215.252
Hs Code.:
DSSTox Substance ID:DTXSID701162616
Nikkaji Number:J725.060F

Synonyms:DTXSID701162616;(4S)-2-Phenyl-4-[(2S,3R)-3-vinyloxiranyl]-2-oxazoline;Oxazole, 4-[(2S,3R)-3-ethenyloxiranyl]-4,5-dihydro-2-phenyl-, (4S)-;173531-24-3

Suppliers and Price of (4S)-2-Phenyl-4-[(2S,3R)-3-vinyloxiranyl]-2-oxazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (4S)-2-Phenyl-4-[(2S,3R)-3-vinyloxiranyl]-2-oxazoline

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:215.094628657
Heavy Atom Count:16
Complexity:307

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C=CC1C(O1)C2COC(=N2)C3=CC=CC=C3
Isomeric SMILES:C=C[C@@H]1[C@@H](O1)[C@@H]2COC(=N2)C3=CC=CC=C3

Technology Process of (4S)-2-Phenyl-4-[(2S,3R)-3-vinyloxiranyl]-2-oxazoline

There total 4 articles about (4S)-2-Phenyl-4-[(2S,3R)-3-vinyloxiranyl]-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 173531-23-2
(1'R,2'R,4S)-1'-Methylsulfonyloxy-1'-(2-phenyl-4,5-dihydrooxazol-4-yl)but-3'-en-2'-ol

: 173531-24-3
(4S,1'S,2'R)-4-(1',2'-Epoxybut-3'-enyl)-2-phenyl-4,5-dihydrooxazole

Guidance literature:: With potassium carbonate; In methanol; 1.) 0 deg C, 30 min, 2.) r.t., 5 h;
DOI:10.1039/p19960000823

Reference yield: 78.0%

: (4S,1'R,2'R,3'R)-4-<2',3'-Epoxy-4'-iodo-1'-(methylsulfonyloxy)butyl>-2-phenyl-4,5-dihydrooxazole

: 173531-24-3
(4S,1'S,2'R)-4-(1',2'-Epoxybut-3'-enyl)-2-phenyl-4,5-dihydrooxazole

Guidance literature:: With n-butyllithium; acetic acid; In tetrahydrofuran; hexane; isopropyl alcohol; 1.) -70 deg C, 10 min, 2.) r.t., 1 h;
DOI:10.1039/p19960000823

Reference yield:

: (2'S,3'R,4'R,4S)-2',3'-Epoxy-4'-(methylsulfonyloxy)-4'-(2-phenyl-4,5-dihydrooxazol-4-yl)butan-1'-ol

: 173531-24-3
(4S,1'S,2'R)-4-(1',2'-Epoxybut-3'-enyl)-2-phenyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1: I₂, Ph₃P, pyridine / CH₂Cl₂ / 2 h / 5 - 10 °C

2: 78 percent / BuLi, AcOH / hexane; tetrahydrofuran; propan-2-ol / 1.) -70 deg C, 10 min, 2.) r.t., 1 h

With pyridine; n-butyllithium; iodine; acetic acid; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1039/p19960000823