<2S-<2α(S^*),3β,11β>>-10-benzyloxy-2-(6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine

Base Information

• Chemical Name: <2S-<2α(S^*),3β,11β>>-10-benzyloxy-2-(6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzo
• Molecular Formula: C₄₁H₄₈N₂O₄
• Molecular Weight: 632.843

Synonyms:<2S-<2α(S^*),3β,11β>>-10-benzyloxy-2-(6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine

Chemical Property of <2S-<2α(S^*),3β,11β>>-10-benzyloxy-2-(6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzo

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There total 4 articles about <2S-<2α(S^*),3β,11β>>-10-benzyloxy-2-(6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(2R,3R,11bS)-10-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine (82514-02-1) → <2S-<2α(R*),3β,11β>>-10-benzyloxy-2-(6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine (107381-02-2) + <2S-<2α(S*),3β,11β>>-10-benzyloxy-2-(6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine (82514-03-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; at 18 ℃; for 1h;

DOI:10.1248/cpb.33.5264

Reference yield:

3-benzyloxy-4-methoxyphenylethylamine (36455-21-7) → <2S-<2α(S*),3β,11β>>-10-benzyloxy-2-(6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine (82514-03-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Et₃N, (EtO)2POCN / dimethylformamide / 6 h / Ambient temperature

2: 87 percent / POCl₃ / toluene / 1.5 h / Heating

3: 48 percent / H₂ / Pt / ethanol / 1 h / 18 °C / 760 Torr

With diethyl cyanophosphonate; hydrogen; triethylamine; trichlorophosphate; platinum; In ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

(2R,3R,11bS)-(-)-10-benzyloxy-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine-2-acetic acid ethyl ester (82310-54-1) → <2S-<2α(S*),3β,11β>>-10-benzyloxy-2-(6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine (82514-03-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / 2 N aq. NaOH / ethanol / 24 h / Ambient temperature

2: 90 percent / Et₃N, (EtO)2POCN / dimethylformamide / 6 h / Ambient temperature

3: 87 percent / POCl₃ / toluene / 1.5 h / Heating

4: 48 percent / H₂ / Pt / ethanol / 1 h / 18 °C / 760 Torr

With sodium hydroxide; diethyl cyanophosphonate; hydrogen; triethylamine; trichlorophosphate; platinum; In ethanol; N,N-dimethyl-formamide; toluene;

upstream raw materials:

(2R,3R,11bS)-10-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine

3-benzyloxy-4-methoxyphenylethylamine

(2R,3R,11bS)-(-)-10-benzyloxy-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine-2-acetic acid ethyl ester

(2R,3R,11bS)-10-benzyloxy-N-(3-benzyloxy-4-methoxyphenethyl)-3-ethyl-1,3,4,6,7,11b-hexahydro-9-methoxy-2H-benzoquinolizine-2-acetamide

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