(E)-methyl 3-(4-(N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-sulfamoyl)phenyl)acrylate

Base Information

Chemical Name:(E)-methyl 3-(4-(N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-sulfamoyl)phenyl)acrylate
CAS No.:1133001-70-3
Molecular Formula:C₂₁H₂₃N₃O₅S₃
Molecular Weight:493.629
Hs Code.:

Synonyms:(E)-methyl 3-(4-(N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-sulfamoyl)phenyl)acrylate

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Chemical Property of (E)-methyl 3-(4-(N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-sulfamoyl)phenyl)acrylate

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Technology Process of (E)-methyl 3-(4-(N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-sulfamoyl)phenyl)acrylate

There total 8 articles about (E)-methyl 3-(4-(N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-sulfamoyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1133001-67-8
(E)-methyl 3-(4-(chlorosulfonyl)phenyl)acrylate

: 224436-97-9
2-amino-5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-thiazole

: 1133001-70-3
(E)-methyl 3-(4-(N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-sulfamoyl)phenyl)acrylate

Guidance literature:: With pyridine; at 20 - 60 ℃; for 4.5h; Inert atmosphere;

Reference yield:

: 76779-98-1
1-azido-3,3-dimethyl-2-butanone

: 1133001-70-3
(E)-methyl 3-(4-(N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-sulfamoyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol

2.1: triethylamine / dichloromethane / 1.25 h / -10 - -5 °C

3.1: trichlorophosphate / 1 h / 105 °C

4.1: ethanol; sodium tetrahydroborate / acetone / 1 h / 20 °C

4.2: 1 h / Reflux

5.1: pyridine / 4.5 h / 20 - 60 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium tetrahydroborate; ethanol; hydrogen; triethylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol; dichloromethane; acetone;

Reference yield:

: 13547-70-1
1-chloro-3,3-dimethyl-butan-2-one

: 1133001-70-3
(E)-methyl 3-(4-(N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-sulfamoyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide / acetone / 25 °C

2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol

3.1: triethylamine / dichloromethane / 1.25 h / -10 - -5 °C

4.1: trichlorophosphate / 1 h / 105 °C

5.1: ethanol; sodium tetrahydroborate / acetone / 1 h / 20 °C

5.2: 1 h / Reflux

6.1: pyridine / 4.5 h / 20 - 60 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium tetrahydroborate; sodium azide; ethanol; hydrogen; triethylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol; dichloromethane; acetone;