2-hydroxy-1,2,2-triphenylethyl *,R^*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

Base Information

• Chemical Name: 2-hydroxy-1,2,2-triphenylethyl *,R^*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate
• CAS No.: 141046-41-5
• Molecular Formula: C₄₂H₃₈FN₃O₄
• Molecular Weight: 667.78

Synonyms:2-hydroxy-1,2,2-triphenylethyl *,R^*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

Chemical Property of 2-hydroxy-1,2,2-triphenylethyl *,R^*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

Chemical Property:

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99% ^*data from raw suppliers

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Technology Process of 2-hydroxy-1,2,2-triphenylethyl *,R^*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

There total 8 articles about 2-hydroxy-1,2,2-triphenylethyl *,R^*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrid-2-ylhydrazine (4930-98-7) → 2-hydroxy-1,2,2-triphenylethyl *,R*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate (141046-41-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 64 percent / acetic acid / 3 h / 60 °C

2: 50 percent / phosphorus oxychloride / 48 h / 70 °C

3: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

4: 66 percent / Raney nickel / formic acid / 60 °C

5: 1.) lithium diisopropylamide, 2.) MgBr₂

With sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; nickel; In formic acid; acetic acid;

DOI:10.1021/jm00089a022

Reference yield:

2-[5-(4-fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyridine (114433-95-3) → 2-hydroxy-1,2,2-triphenylethyl *,R*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate (141046-41-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 50 percent / phosphorus oxychloride / 48 h / 70 °C

2: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

3: 66 percent / Raney nickel / formic acid / 60 °C

4: 1.) lithium diisopropylamide, 2.) MgBr₂

With sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; nickel; In formic acid;

DOI:10.1021/jm00089a022

Reference yield:

1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione (114433-94-2) → 2-hydroxy-1,2,2-triphenylethyl *,R*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate (141046-41-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 64 percent / acetic acid / 3 h / 60 °C

2: 50 percent / phosphorus oxychloride / 48 h / 70 °C

3: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

4: 66 percent / Raney nickel / formic acid / 60 °C

5: 1.) lithium diisopropylamide, 2.) MgBr₂

With sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; nickel; In formic acid; acetic acid;

DOI:10.1021/jm00089a022

upstream raw materials:

pyrid-2-ylhydrazine

1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

2-[5-(4-fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyridine

2-[4-bromo-5-(4-fluoro-phenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyridine

Downstream raw materials:

1,1-dimethylethyl *,S^*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate

1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate

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