3-(N-prolylamine)-2-oxo-1-pyrrolidineacetamide

Base Information

Chemical Name:3-(N-prolylamine)-2-oxo-1-pyrrolidineacetamide
CAS No.:106732-52-9
Molecular Formula:C₁₁H₁₈N₄O₃
Molecular Weight:254.289
Hs Code.:
Mol file:106732-52-9.mol

Synonyms:1-Pyrrolidineacetamide,2-oxo-3-[(2-pyrrolidinylcarbonyl)amino]-, [S-(R*,R*)]-

Suppliers and Price of 3-(N-prolylamine)-2-oxo-1-pyrrolidineacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 8 raw suppliers

Chemical Property of 3-(N-prolylamine)-2-oxo-1-pyrrolidineacetamide

Chemical Property:

Vapor Pressure:1.18E-16mmHg at 25°C
Boiling Point:647.6°Cat760mmHg
Flash Point:345.4°C
PSA：109.01000
Density:1.33g/cm³
LogP:0.19750

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-(N-prolylamine)-2-oxo-1-pyrrolidineacetamide

There total 6 articles about 3-(N-prolylamine)-2-oxo-1-pyrrolidineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 114200-40-7
3(S)-<amino>-2-oxo-1-pyrrolidineacetamide

: 106732-52-9
3(S)-(N-L-prolylamino)-2-oxo-1-pyrrolidineacetamide

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In methanol; under 2068.6 Torr;
DOI:10.1021/jm00402a031

Reference yield:

: 79839-26-2,116339-45-8
3(S)-[(tert-butyloxycarbonyl)amino]-2-oxo-1-pyrrolidineacetic acid

: 106732-52-9
3(S)-(N-L-prolylamino)-2-oxo-1-pyrrolidineacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / methanol; diethyl ether / 2 h / Ambient temperature

2: aq. HCl / dioxane / 0.33 h / 0 °C

3: diphenyl phosphorazidate, Et₃N / dimethylformamide / 1) 0 deg C, 2 d; 2) room temperature, overnight

4: NH₃ / methanol / 12 h / Ambient temperature

5: 40 percent / Et₃N, H₂ / Pd/C / methanol / 2068.6 Torr

With hydrogenchloride; diphenyl phosphoryl azide; ammonia; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a031

Reference yield:

: 79839-23-9
Boc-Met-Gly methyl ester methylsulfonium iodide

: 106732-52-9
3(S)-(N-L-prolylamino)-2-oxo-1-pyrrolidineacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 53 percent / NaH / dimethylformamide / 1) 4 deg C, 5 min; 2) room temperature, 15 min

2: 93 percent / methanol; diethyl ether / 2 h / Ambient temperature

3: aq. HCl / dioxane / 0.33 h / 0 °C

4: diphenyl phosphorazidate, Et₃N / dimethylformamide / 1) 0 deg C, 2 d; 2) room temperature, overnight

5: NH₃ / methanol / 12 h / Ambient temperature

6: 40 percent / Et₃N, H₂ / Pd/C / methanol / 2068.6 Torr

With hydrogenchloride; diphenyl phosphoryl azide; ammonia; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a031