(R,S)-3-[(4-{(1E)-3-[(tert-butoxycarbonyl)(ethyl)amino]-4-methylpent-1-en-1-yl}phenyl)carbonyl]-2-ethylindolizine-7-carboxylic acid

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Chemical Name:(R,S)-3-[(4-{(1E)-3-[(tert-butoxycarbonyl)(ethyl)amino]-4-methylpent-1-en-1-yl}phenyl)carbonyl]-2-ethylindolizine-7-carboxylic acid
CAS No.:1376437-46-5
Molecular Formula:C₃₁H₃₈N₂O₅
Molecular Weight:518.653
Hs Code.:

Synonyms:(R,S)-3-[(4-{(1E)-3-[(tert-butoxycarbonyl)(ethyl)amino]-4-methylpent-1-en-1-yl}phenyl)carbonyl]-2-ethylindolizine-7-carboxylic acid

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Chemical Property of (R,S)-3-[(4-{(1E)-3-[(tert-butoxycarbonyl)(ethyl)amino]-4-methylpent-1-en-1-yl}phenyl)carbonyl]-2-ethylindolizine-7-carboxylic acid

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Technology Process of (R,S)-3-[(4-{(1E)-3-[(tert-butoxycarbonyl)(ethyl)amino]-4-methylpent-1-en-1-yl}phenyl)carbonyl]-2-ethylindolizine-7-carboxylic acid

There total 7 articles about (R,S)-3-[(4-{(1E)-3-[(tert-butoxycarbonyl)(ethyl)amino]-4-methylpent-1-en-1-yl}phenyl)carbonyl]-2-ethylindolizine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1376437-45-4
propan-2-yl (R,S)-3-[(4-{(1E)-3-[(tert-butoxycarbonyl)(ethyl)amino]-4-methylpent-1-en-1-yl}phenyl)carbonyl]-2-ethylindolizine-7-carboxylate

: 1376437-46-5
(R,S)-3-[(4-{(1E)-3-[(tert-butoxycarbonyl)(ethyl)amino]-4-methylpent-1-en-1-yl}phenyl)carbonyl]-2-ethylindolizine-7-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 0 - 25 ℃; for 18h;

Reference yield:

: 1376437-43-2
N²-(tert-butoxycarbonyl)-N₂-ethyl-N-methoxy-N-methyl-D,L-valinamide

: 1376437-46-5
(R,S)-3-[(4-{(1E)-3-[(tert-butoxycarbonyl)(ethyl)amino]-4-methylpent-1-en-1-yl}phenyl)carbonyl]-2-ethylindolizine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / -78 - 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 18 h / -78 - 25 °C

3.1: water; sodium hydroxide / methanol; tetrahydrofuran / 18 h / 0 - 25 °C

With lithium aluminium tetrahydride; water; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; mineral oil;

Reference yield:

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 1376437-46-5
(R,S)-3-[(4-{(1E)-3-[(tert-butoxycarbonyl)(ethyl)amino]-4-methylpent-1-en-1-yl}phenyl)carbonyl]-2-ethylindolizine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / chlorobenzene / 2 h / Reflux

2.1: 3 h / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 18 h / -78 - 25 °C

4.1: water; sodium hydroxide / methanol; tetrahydrofuran / 18 h / 0 - 25 °C

With pyridine; water; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; chlorobenzene; mineral oil;